Intraarterial cisplatin in the management of stage IIB osteosarcoma in the pediatric and adolescent age group.
Intraarterial cisplatin in the management of stage IIB osteosarcoma in the pediatric and adolescent age group.
复制标题
动脉内顺铂治疗儿童和青少年年龄组 IIB 期骨肉瘤。
DOI：
--
复制
发表时间：
1991
影响因子：
4.2
通讯作者：
R. Robertson
中科院分区：
文献类型：
--
作者：
Norman Jaffe;Debra Smith;Mark Robert Jaffe;Melissa Hudson;Humberto Carrasco;Sidney Wallace;A. Ayala;John A. Murray;R. Robertson
对60例四肢骨肉瘤患者行顺铂动脉灌注治疗。随后采用两种不同的方案进行手术切除（截肢或保肢）和术后辅助化疗。75%的患者获得了初步缓解。总体无病生存率为58%。保肢手术治疗的患者数量逐渐增加，80%的新登记患者获得反应并接受保肢手术。截肢患者的无病生存率为48%，保肢患者的无病生存率为68%。在确定无病生存率方面，唯一有预后意义的因素是术前化疗引起的肿瘤破坏程度和肿瘤大小。
Sixty patients with extremity osteosarcoma were treated with intraarterial cisplatin. This was followed by surgical resection (amputation or limb salvage) and postoperative adjuvant chemotherapy utilizing two different protocols. Seventy-five percent of patients achieved an initial response. Overall disease-free survival was 58%. The number of patients treated with limb-salvage surgery gradually increased to the extent that 80% of newly-registered patients achieved a response and were subjected to limb salvage. Disease-free survival was 48% in amputation and 68% in limb salvage. The only factors found to have prognostic significance in determining disease-free survival were extent of tumor destruction induced by preoperative chemotherapy and tumor size.
影响因子：
158.5
作者：
LINK, MP;GOORIN, AM;VIETTI, TJ
通讯作者：
VIETTI, TJ