Evolutionary strategies of Bdellovibrio bacteriovorus predators and prey
Evolutionary strategies of Bdellovibrio bacteriovorus predators and prey
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食菌蛭弧菌捕食者和猎物的进化策略
DOI：
10.1099/acmi.ac2019.po0369
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发表时间：
2019
影响因子：
--
通讯作者：
Summers K
中科院分区：
文献类型：
--
作者：
Summers K
抗生素耐药性是对人类健康的严重威胁，迫切需要新的细菌感染治疗方法。20世纪初首次使用的噬菌体和捕食性细菌（1962年发现）是抗生素的潜在替代品。我们建立了一个捕食者和猎物的数学模型来探讨蛭弧菌和噬菌体对猎物细菌数量的影响。我们的系统有一种非生物资源，被电子消耗。具有Monod动力学和Holling I型或II型功能反应的多达两种捕食者。由于蛭形弧菌作为“蛭形体”在其猎物的周质中花费了相当长的时间，这一阶段也被建模，在猎物移除和捕食者“出生”之间有一个延迟。我们使用该模型来检查蛭弧菌和噬菌体对猎物种群的影响，并发现蛭弧菌和噬菌体在有效性上存在明显差异。我们还研究了各种生物因素是如何改变捕食效率的。我们发现，对于捕食者来说，存在一个最佳的捕食者：猎物比例。我们还发现，对于掠食者来说，存在一个最佳攻击率和最佳死亡率。
Antibiotic resistance is a serious threat to human health and new treatments for bacterial infections are urgently needed. Bacteriophages, first used at the beginning of the 20th century, and the predatory bacterium Bdellovibrio bacteriovorus (discovered in 1962) are potential alternatives to antibiotics. We developed a mathematical predator prey model to explore the effects of Bdellovibrio and bacteriophage on prey bacterial numbers. Our system has an abiotic resource that is consumed by theE. coliprey following Monod kinetics and up to two predator species with Holling type I or type II functional responses. As Bdellovibrio spends considerable time in the periplasm of its prey as a ‘bdelloplast’, this stage is also modelled, giving a delay between prey removal and ‘birth’ of predators. We used the model to examine the effects of Bdellovibrio and a bacteriophage on prey populations and found a distinct difference in effectiveness between Bdellovibrio and bacteriophages. We also looked at how various biological factors change predation effeciency. We found that there is an optimal predator:prey ratio for the predator. We also discovered that there is an optimal attack rate and an optimal mortality for the predator.