PROGRESSIVE ENCEPHALOPATHY IN CHILDREN WITH ACQUIRED IMMUNE-DEFICIENCY SYNDROME
PROGRESSIVE ENCEPHALOPATHY IN CHILDREN WITH ACQUIRED IMMUNE-DEFICIENCY SYNDROME
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DOI：
10.1002/ana.410170512
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发表时间：
1985-01-01
影响因子：
11.2
通讯作者：
OLESKE, JM
中科院分区：
文献类型：
--
作者：
EPSTEIN, LG;SHARER, LR;OLESKE, JM
We are reporting the cases of four children with a diagnosis of acquired immune deficiency syndrome (AIDS) who demonstrated a progressive encephalopathy manifested by loss of motor milestones or intellectual abilities, and weakness with pyramidal tract signs. Two patients were ataxic. One child was cortically blind and suffered myoclonic jerks before his death. Two of the patients had isolated seizures at some time during the disease course. Two patients developed secondary microcephaly and all four patients showed cortical atrophy on computed tomographic scanning. Three of the patients died. Postmortem neuropathological findings included gross cortical atorphy, microglial nodules, and intranuclear inclusions, as are described in the subacute encephalitis reported in adult AIDS patients. We propose that the possible pathogenetic mechanisms of the encephalopathy include opportunistic or persistent viral infection of the brain.
