Multislice imaging of quantitative cerebral perfusion with pulsed arterial spin labeling
Multislice imaging of quantitative cerebral perfusion with pulsed arterial spin labeling
复制标题
DOI：
10.1002/mrm.1910390520
复制
发表时间：
1998-05-01
影响因子：
3.3
通讯作者：
Duyn, JH
中科院分区：
文献类型：
--
作者：
Yang, YH;Frank, JA;Duyn, JH
提出了一种基于动脉自旋磁标记的多层定量脑灌注测量方法。该方法结合了脉冲动脉反转，称为FAIR（流量敏感交替反转恢复）实验，与快速螺旋扫描图像采集。螺旋数据采集的持续时间短（22 ms），每个标记周期可同时测量多达10个切片，因此与当前的单切片采集协议相比，大大提高了效率。标记效率的调查，抑制不必要的信号从静止以及动脉内自旋，和FAIR信号的变化作为反转延迟的函数，定量脑血流量（CBF）的评估与新技术的演示和显示，需要测量动脉通过时间以及抑制动脉内自旋信号。正常志愿者的CBF测量值与H2O15正电子发射断层扫描（PET）研究酸其他放射性示踪剂方法获得的结果一致。此外，新方法允许在手指敲击实验中检测激活相关的灌注变化，激活位置与血氧水平依赖（BOLD）fMRI观察到的位置相对应。
A method is presented for multislice measurements of quantitative cerebral perfusion based on magnetic labeling of arterial spins. The method combines a pulsed arterial inversion, known as the FAIR (Flow-sensitive Alternating Inversion Recovery) experiment, with a fast spiral scan image acquisition. The short duration (22 ms) of the spiral data collection allows simultaneous measurement of up to 10 slices per labeling period, thus dramatically increasing efficiency compared to current single slice acquisition protocols. Investigation of labeling efficiency, suppression of unwanted signals from stationary as well as intraarterial spins, and the FAIR signal change as a function of inversion delay are presented, The assessment of quantitative cerebral blood flow (CBF) with the new technique is demonstrated and shown to require measurement of arterial transit time as well as suppression of intraarterial spin signals. CBF values measured on normal volunteers are consistent with results obtained from H2O15 positron emission tomography (PET) studies acid other radioactive tracer approaches. In addition, the new method allows detection of activation-related perfusion changes in a finger-tapping experiment, with locations of activation corresponding well to those observed with blood oxygen level dependent (BOLD) fMRI.