Circumpapillary retinal nerve fiber layer thickness, anterior lamina cribrosa depth, and lamina cribrosa thickness in neovascular glaucoma secondary to proliferative diabetic retinopathy: a cross-sectional study.
Circumpapillary retinal nerve fiber layer thickness, anterior lamina cribrosa depth, and lamina cribrosa thickness in neovascular glaucoma secondary to proliferative diabetic retinopathy: a cross-sectional study.
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DOI：
10.1186/s12886-017-0456-9
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发表时间：
2017-04-26
影响因子：
2
通讯作者：
Inatani M
中科院分区：
文献类型：
--
作者：
Yokota S;Takihara Y;Takamura Y;Inatani M
应用增强深度成像光谱域光学相干断层扫描技术比较新生血管性青光眼(NVG)患者与非新生血管性青光眼(NVG)患者的筛板。46例增殖性糖尿病视网膜病变患者参加了这项横断面研究。根据NVG的存在与否将患者分为两组(非NVG组和NVG组)。比较两组的眼压(IOP)、视网膜乳头周围神经纤维层(CpRNFL)厚度、筛板前层厚度(ALD)和板层厚度(LT)。非NVG组平均年龄66.2±22.4(平均标准差)岁，平均最大眼压18.8±11.8 mm Hg，平均cpRNFL厚度91.2±22.9μm，平均眼压407.0±22.9μm，平均LT 155.0±24.7μm，NVG组平均年龄61.4±52.1岁，平均最高眼压33.1±31.6μ，平均cpRNFL厚度73.6±33.4 mm。平均眼压为403.9±20.1nμm，平均眼压为156.9±44.2nμm，眼压明显升高，cpRNFL明显变薄(P(分别为0.001和P=0.002)。然而，年龄、ALD和LT在两组间无统计学差异(P值分别为0.151、0.919和0.757)。NVG组虽然cpRNFL较薄，但筛板结构无明显变化。NVG患者视网膜神经节细胞轴突丢失先于筛板变形。本文的在线版本(doi：10.1186/s12886-0170456-9)包含补充材料，授权用户可以使用。
To compare the lamina cribrosa between eyes with and without neovascular glaucoma (NVG) using enhanced depth imaging spectral-domain optical coherence tomography. Forty-six patients with proliferative diabetic retinopathy were enrolled in this cross-sectional study. The patients were divided into two groups based on the absence or presence of NVG (the non-NVG group and the NVG group, respectively). The intraocular pressure (IOP), circumpapillary retinal nerve fiber layer (cpRNFL) thickness, anterior lamina cribrosa depth (ALD), and laminar thickness (LT) were compared between the groups. In the non-NVG group, the mean age was 66.2 ± 2.4 (mean ± standard error) years, mean maximum IOP was 18.8 ± 1.8 mmHg, mean cpRNFL thickness was 91.2 ± 3.9 μm, mean ALD was 407.0 ± 22.9 μm, and mean LT was 155.0 ± 4.7 μm. In the NVG group, the mean age was 61.4 ± 2.1 years, mean maximum IOP was 33.1 ± 1.6 mmHg, mean cpRNFL thickness was 73.6 ± 3.4 μm, mean ALD was 403.9 ± 20.1 μm, and mean LT was 156.9 ± 4.2 μm. The IOP was significantly higher and the cpRNFL was significantly thinner in the NVG group (P < 0.001 and P = 0.002, respectively). However, the age, ALD, and LT were not statistically different between the groups (P = 0.151, 0.919, and 0.757, respectively). Although the cpRNFL was thinner, the structure of the lamina cribrosa was unchanged in the NVG eyes. Axonal loss of the retinal ganglion cells in NVG patients was prior to lamina cribrosa deformation. The online version of this article (doi:10.1186/s12886-017-0456-9) contains supplementary material, which is available to authorized users.