Mutation induction in the male recombination strains of Drosophila melanogaster.
Mutation induction in the male recombination strains of Drosophila melanogaster.
复制标题
果蝇雄性重组株的突变诱导。
作者：
B. Slatko;Y. Hiraizumi
从德克萨斯州南部的黑腹果蝇种群中分离出的一组第二染色体系，已知显示出相对较高的雄性重组频率，被发现将性连锁隐性致死突变的频率从对照频率0.18%增加到1.63%。第二组显示男性重组的频率大大降低，发现导致轻微增加至0.48%，尽管没有统计学意义。第一组还测试了第二条染色体的隐性致死突变频率;频率从对照频率0.28%增加到2.82%。部分伴性致死性染色体的定位显示，尽管有向X染色体顶端聚集的趋势，但仍沿着整个X染色体分布。到目前为止，发现一个性连锁致死系与倒位相关（近似断点，14 A-18 A）。有人认为，引起雄性重组的元件可能与伊韦斯（1950）早期研究的hi mutator基因相似。
One group of the second chromosome lines isolated from a southern Texas population of Drosophila melanogaster, which has been known to show relatively high frequencies of male recombinations, was found to increase the frequency of sex-linked recessive lethal mutations from a control frequency of 0.18% to 1.63%. The second group, which showed a very much reduced frequency of male recombinations, was found to cause a slight increase to 0.48%, although it was not statistically significant. The first group was also tested for the recessive lethal mutation frequency in the second chromosome; the frequency increased from a control frequency of 0.28% to 2.82%. Mapping of a portion of the sex-linked lethals indicated a distribution along the entire X chromosome, although there was a tendency of clustering towards the tip of the X chromosome. One sex-linked lethal line so far tested was found to be associated with an inversion (approximate breakpoints, 14A-18A). It was suggested that the element causing male recombination might be similar to the hi mutator gene studied earlier by Ives (1950).