Estimating Incidence of Acute Heart Failure Syndromes in Japan - An Analysis From the KUNIUMI Registry -
Estimating Incidence of Acute Heart Failure Syndromes in Japan - An Analysis From the KUNIUMI Registry -
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DOI：
10.1253/circj.cj-20-1154
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发表时间：
2021-10-01
影响因子：
3.3
通讯作者：
Hirata, Ken-ichi
中科院分区：
文献类型：
--
作者：
Fujimoto, Wataru;Toh, Ryuji;Hirata, Ken-ichi
背景：在日本，很少有登记机构提供关于急性心力衰竭综合征（AHFS）发病率的准确信息。方法与结果：Awaji岛所有拥有急诊床位的医院都参加了Awaji医疗中心神户大学心力衰竭登记（KUNIUMI registry），这是一项基于人群的回顾性AHFS登记研究，使Awaji岛几乎所有AHFS患者都被登记。从2015年1月1日至2017年12月31日，共有743例新发AHFS患者登记。平均年龄82.1±11.5岁。以日本2015年的一般人群为标准，经年龄和性别调整的AHFS发病率为男性133.8 / 10万人年，女性120.0 / 10万人年。2015年，估计有159,702例新发AHFS患者，预计到2040年将增加到252,153例，并达到平台期。2015年bb0 ~ 85岁患者占比42.6%，预计2040年将增至62.5%。2015年估计保留射血分数的心力衰竭患者比例为52.0%，预计到2055年将逐渐增加到57.3%。结论：本分析提示，随着年龄的增长，日本新发AHFS患者数量不断增加。迫切需要制定应对日益扩大的HF负担的对策。
Background: Few registries have provided precise information concerning incidence rates for acute heart failure syndrome (AHFS) in Japan.Methods and Results: All hospitals with acute care beds in Awaji Island participated in the Kobe University heart failure registry in Awaji Medical Center (KUNIUMI Registry), a retrospective, population-based AHFS registration study, enabling almost every patient with AHFS in Awaji Island to be registered. From 1 January 2015 to 31 December 2017, 743 patients with de novo AHFS had been registered. Mean age was 82.1 +/- 11.5 years. Using the general population of Japan as of 2015 as a standard, age- and sex-adjusted incidence rates for AHFS were 133.8 per 100,000 person-years for male and 120.0 for female. In 2015, there were an estimated 159,702 new-onset patients with AHFS, which was predicted to increase to 252,153 by 2040, and reach a plateau. The proportion of patients aged >85 years accounted for 42.6% in 2015, which was predicted to increase up to 62.5% in 2040. The proportion of patients with heart failure with preserved ejection fraction was estimated at 52.0% in 2015, which was predicted to increase gradually to 57.3% in 2055.Conclusions: The present analysis suggested that the number of patients with de novo AHFS keeps increasing with progressive aging in Japan. Establishment of countermeasures against the expanding burden of HF is urgently required.