Neuregulin and erbB receptors play a critical role in neuronal migration
Neuregulin and erbB receptors play a critical role in neuronal migration
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DOI：
10.1016/s0896-6273(00)80346-3
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发表时间：
1997-07-01
期刊：
影响因子：
16.2
通讯作者：
Corfas, G
中科院分区：
文献类型：
--
作者：
Rio, C;Rieff, HI;Corfas, G
神经前体沿径向胶质纤维的迁移是神经系统形成的关键步骤。在本报告中，我们发现神经调节蛋白erbb受体信号在小脑颗粒细胞沿径向胶质纤维迁移中起着至关重要的作用。在发育中的小脑和体外，颗粒细胞表达神经调节蛋白（NRG），放射状胶质细胞表达erbB4。当神经胶质erbB受体被阻断时，神经元不能诱导径向胶质细胞形成，其沿径向胶质纤维的迁移受到损害。此外，可溶性NRG在诱导径向胶质细胞形成方面与神经元-胶质细胞接触一样有效。这些结果表明NRG激活胶质细胞erbB4是神经元迁移程序的早期关键步骤。
The migration of neuronal precursors along radial glial fibers is a critical step in the formation of the nervous system. In this report, we show that neuregulin-erbB receptor signaling plays a crucial role in the migration of cerebellar granule cells along radial glial fibers. Granule cells express neuregulin (NRG), and radial glia cells express erbB4 in the developing cerebellum and in vitro. When the glial erbB receptors are blocked, neurons fail to induce radial glia formation, and their migration along radial glial fibers is impaired. Moreover, soluble NRG is as effective as neuron-glia contact in the induction of radial glia formation. These results suggest that the activation of glial erbB4 by NRG is an early critical step in the neuronal migration program.