Guanine Nucleotide‐Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1–Related Inflammation and Lipophagy
Guanine Nucleotide‐Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1–Related Inflammation and Lipophagy
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DOI：
10.1002/hep.32078
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发表时间：
2021-07
期刊：
影响因子：
13.5
通讯作者：
Zechuan Zhang;Zetao Ji;Jianbo He;Yijun Lu;W. Tian;C. Zheng;Huihui Chen;Quan Zhang;Fei Yang;Minglu Zhang;Yin Yin-Yin;R. Jiang;Wen‐Ming Chu;Wenjie Zhang;Beicheng Sun
中科院分区：
文献类型：
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作者：
Zechuan Zhang;Zetao Ji;Jianbo He;Yijun Lu;W. Tian;C. Zheng;Huihui Chen;Quan Zhang;Fei Yang;Minglu Zhang;Yin Yin-Yin;R. Jiang;Wen‐Ming Chu;Wenjie Zhang;Beicheng Sun
NASH is an advanced stage of liver disease accompanied by lipid accumulation, inflammation, and liver fibrosis. Guanine nucleotide‐binding protein G(i) subunit alpha‐2 (GNAI2) is a member of the “inhibitory” class of α‐subunits, and recent studies showed that Gnai2 deficiency is known to cause reduced weight in mice. However, the role of GNAI2 in hepatocytes, particularly in the context of liver inflammation and lipid metabolism, remains to be elucidated. Herein, we aim to ascertain the function of GNAI2 in hepatocytes and its impact on the development of NASH.
