Prognostic value of IL-34 in colorectal cancer patients.
Prognostic value of IL-34 in colorectal cancer patients.
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DOI：
10.1080/25785826.2019.1691429
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发表时间：
2019-12-01
影响因子：
4.4
通讯作者：
Seino, Ken-Ichiro
中科院分区：
文献类型：
--
作者：
Kobayashi, Takuto;Baghdadi, Muhammad;Seino, Ken-Ichiro
在包括美国在内的一些国家，结直肠癌的死亡率预计会增加，这就需要识别新的分子来帮助评估预后和改善生存。在这份简短的报告中，我们评估了白细胞介素34(IL-34)作为结直肠癌预后因素的潜力。IL-34在2008年首次被报道为一种新的细胞因子，控制髓系细胞的生物学。越来越多的证据表明，IL-34在改善肿瘤微环境、提高肿瘤治疗耐药性方面具有重要作用。在这项研究中，我们发现，除了一组日本结直肠癌患者的原发癌组织外，各种结直肠癌细胞系中都可以检测到IL-34的表达，从高到低不等。Kaplan-Meier分析显示，IL-34的高表达与结直肠癌患者的生存不良有关。重要的是，在单因素和多因素分析中，IL-34的高表达与不良预后相关。在癌症基因组图谱中登记的一组结直肠癌患者中，也观察到IL-34的表达与较差的预后之间存在类似的关系。综上所述，这些发现表明IL-34作为结直肠癌预后因子的潜在作用。
The mortality of colorectal cancer is expected to increase in some countries including the United States, which necessitates the identification of new molecules that help in prognosis assessment and survival improvement. In this brief report, we evaluated the potential of interleukin-34 (IL-34) as a prognostic factor in colorectal cancer. IL-34 was reported for the first time in 2008 as a novel cytokine that controls the biology of the myeloid cell lineage. Accumulating evidence suggests important roles for IL-34 in modifying the tumor microenvironment and enhancing therapeutic resistance of cancer. In this study, we found that IL-34 expression was detectable in various colorectal cancer cell lines in addition to primary cancer tissues from a cohort of Japanese colorectal cancer patients, ranging from high to absent. A Kaplan-Meier analysis showed that high expression of IL-34 correlated with poor survival of colorectal cancer patients. Importantly, in both univariate and multivariate analysis, high IL-34 expression correlated with unfavorable prognosis. A similar relationship between IL-34 expression and the poorer prognosis was also observed in a cohort of colorectal cancer patients registered at The Cancer Genome Atlas. Together, these findings indicate a potential role for IL-34 as a prognostic factor in colorectal cancer.