3D printing of a biocompatible low molecular weight supramolecular hydrogel by dimethylsulfoxide water solvent exchange
3D printing of a biocompatible low molecular weight supramolecular hydrogel by dimethylsulfoxide water solvent exchange
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DOI：
10.1016/j.addma.2020.101162
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发表时间：
2020-05-01
影响因子：
11
通讯作者：
Fitremann, Juliette
中科院分区：
文献类型：
--
作者：
Chalard, Anais;Mauduit, Morgane;Fitremann, Juliette
通过溶剂交换过程将易碎且非触变的生物相容性低分子量凝胶打印成3D结构。3D打印过程是基于连续挤出一种小的两亲分子N-庚基-D-半乳糖酰胺在二甲亚砜中的溶液，该溶液与水接触形成凝胶。水在二甲基亚砜/N-庚基-D-半乳糖酰胺溶液中的扩散触发分子自组装成超分子纤维和油墨的凝固。得到一个明确的模式和结构的尺寸的条件已经确定。所得到的结构可以很容易地溶解，定向其应用作为牺牲油墨或临时支持。该方法为其他易碎和非触变性超分子水凝胶的注射和3D打印开辟了道路。
A fragile and non-thixotropic biocompatible low molecular weight gel is printed in 3D structures by a solvent exchange process. The 3D printing process is based on the continuous extrusion of a solution of a small amphiphile molecule, N-heptyl-D-galactonamide, in dimethylsulfoxide, that forms a gel in contact with water. The diffusion of water in the dimethylsulfoxide / N-heptyl-D-galactonamide solution triggers the self-assembly of the molecule into supramolecular fibers and the setting of the ink. The conditions for getting a well-defined pattern and the dimensions of the constructs have been determined. The resulting constructs can be easily dissolved, orienting its application as a sacrificial ink or a temporary support. This method opens the way to the injection and the 3D printing of other fragile and non-thixotropic supramolecular hydrogels.