Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects
Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects
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DOI：
10.1007/s10038-007-0231-5
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发表时间：
2008-02-01
影响因子：
3.5
通讯作者：
Kasuga, Masato
中科院分区：
文献类型：
--
作者：
Miyake, Kazuaki;Horikawa, Yukio;Kasuga, Masato
转录因子7样2（TCF7L2）已被证明与多个种族的2型糖尿病相关。关于亚洲人群，Horikoshi等人（Diabetologia 50：747 - 751，2007）和Hayashi等人（Diabetologia 50：980 - 984，2007）报道了TCF 7L2中的单核苷酸多态性（SNP）与日本人群中的2型糖尿病相关，而对于中国汉族人群报道了矛盾的结果。这项研究的目的是调查TCF 7L2基因与2型糖尿病的关联，使用相对较大的样本量：2，214名日本2型糖尿病患者和1，873名正常对照。在合并样本集中，次要等位基因rs7903146、rs11196205和rs12255372与2型糖尿病显著相关（OR = 1.48，P = 2.7 x 10（-4）; OR = 1.39，P = 4.6 x 10（-4）; OR = 1.70，P = 9.8 x 10（-5））。然而，rs11196218和rs290487均未显示出显著关联。这些结果表明，TCF 7L2是日本人群中2型糖尿病的重要易感基因。
Transcription factor 7-like 2 (TCF7L2) has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups. Regarding the Asian population, Horikoshi et al. (Diabetologia 50:747-751, 2007) and Hayashi et al. (Diabetologia 50:980-984, 2007) reported that single nucleotide polymorphisms (SNPs) in TCF7L2 were associated with type 2 diabetes in the Japanese population, while contradictory results were reported for Han Chinese populations. The aim of this study was to investigate the associations of the TCF7L2 gene with type 2 diabetes using a relatively large sample size: 2,214 Japanese individuals with type 2 diabetes and 1,873 normal controls. The minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 2 diabetes (OR = 1.48, P = 2.7 x 10(-4); OR = 1.39, P = 4.6 x 10(-4); OR = 1.70, P = 9.8 x 10(-5), respectively) in the combined sample sets. However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population.