A career pathway in protein folding: from model peptides to postreductionist protein science.
A career pathway in protein folding: from model peptides to postreductionist protein science.
复制标题
蛋白质折叠的职业道路：从模型肽到后还原蛋白质科学。
DOI：
10.1002/pro.615
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Gierasch,LilaM
中科院分区：
文献类型：
--
作者：
Gierasch,LilaM
This review discusses the inherent challenge of linking “reductionist” approaches to decipher the information encoded in protein sequences with burgeoning efforts to explore protein folding in native environments—“postreductionist” approaches. Because the invitation to write this article came as a result of my selection to receive the 2010 Dorothy Hodgkin Award of the Protein Society, I use examples from my own work to illustrate the evolution from the reductionist to the postreductionist perspective. I am incredibly honored to receive the Hodgkin Award, but I want to emphasize that it is the combined effort, creativity, and talent of many students, postdoctoral fellows, and collaborators over several years that has led to any accomplishments on which this selection is based. Moreover, I do not claim to have unique insight into the topics discussed here; but this writing opportunity allows me to illustrate some threads in the evolution of protein folding research with my own experiences and to point out to those embarking on careers how the twists and turns in anyone's scientific path are influenced and enriched by the scientific context of our research. The path my own career has taken thus far has been shaped by the timing of discoveries in the field of protein science; together with our contemporaries, we become part of a knowledge evolution. In my own case, this has been an epoch of great discovery in protein folding and I feel very fortunate to have participated in it.
