The multiple origins of cooperativity in binding to multi‐site lattices
The multiple origins of cooperativity in binding to multi‐site lattices
复制标题
与多位点晶格结合的协同性的多重起源
DOI：
10.1016/s0014-5793(96)01020-4
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发表时间：
1996
期刊：
影响因子：
3.5
通讯作者：
H. Saroff
中科院分区：
文献类型：
--
作者：
D. Sackett;H. Saroff
涉及配体与结合位点聚合晶格可逆缔合的结合事件在生物学中很常见，并且经常在结合中表现出显着的协同性。与仅基于组合考虑的简单、独立的结合事件预期的结合相比，可以通过多重结合的结合曲线的特征变化来检测结合中的正协同性和负协同性。协同性源自与结合本身不同的配体依赖性相互作用。配体依赖性最近邻相互作用可以有两种类型，称为配体-晶格（仅当结合的配体不相邻时才会发生）和配体-配体（如果两个或更多个结合的配体相邻则可能发生）。这两种协同性来源的分子机制并不相同。相同的协同结合曲线可以通过代表这些相互作用类型中的一种或两种的参数的统一的变化来产生。正协同性同样可能由不利于初始、不相邻结合的不稳定配体-晶格相互作用、有利于后续、相邻结合的稳定配体-配体相互作用或两者共同产生。它们的结构起源不同，协同性可能来自多种结构相互作用。
Binding events involving the reversible association of ligands with polymeric lattices of binding sites are common in biology and frequently exhibit significant cooperativity in binding. Positive and negative cooperativity in binding may be detected by characteristic changes in binding curves for multiple binding, compared to the binding expected for simple, independent binding events that are based on combinatorial considerations only. Cooperativity arises from ligand-dependent interactions distinct from binding per se. Ligand-dependent nearest neighbor interactions may be of two types referred to as ligand-lattice (which can only occur if a bound ligand is unneighbored) and ligand-ligand (which can occur if two or more bound ligands are adjacent). The molecular mechanisms underlying these two sources of cooperativity are not the same. Identical cooperative binding curves may be produced by changes from unity in parameters representing either one or both of these interaction types. Positive cooperativity may equally result from destabilizing ligand-lattice interactions that disfavor initial, unneighbored binding, stabilizing ligand-ligand interactions that favor subsequent, neighbored binding, or both. The structural origins of these are different, and cooperativity may emerge from multiple structural interactions.
微管相关蛋白2与微管的平衡结合机制。
DOI：
--
发表时间：
1993
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Wallis,KT;Azhar,S;Rho,MB;Lewis,SA;Cowan,NJ;Murphy,DB
通讯作者：
Murphy,DB
影响因子：
56.9
作者：
STRAUSS, JK;MAHER, LJ
通讯作者：
MAHER, LJ