Effect of Android to Gynoid Fat Ratio on Insulin Resistance in Obese Youth
Effect of Android to Gynoid Fat Ratio on Insulin Resistance in Obese Youth
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DOI：
10.1001/archpediatrics.2009.148
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发表时间：
2009-09-01
影响因子：
--
通讯作者：
Duche, Pascale
中科院分区：
文献类型：
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作者：
Aucouturier, Julien;Meyer, Martine;Duche, Pascale
背景资料：上半身脂肪分布与肥胖儿童和青少年胰岛素抵抗的早期发展相关目的：确定男性与女性脂肪比例是否与肥胖儿童和青少年胰岛素抵抗的严重程度相关，而外周皮下脂肪可能对胰岛素抵抗具有保护作用。一项回顾性分析，使用的数据从医疗咨询2005年1月至2007年1月。参与者：来自66名肥胖儿童和青少年来医院进行医疗咨询的数据被用于本研究。主要结果Measures：受试者被分层到三分位数的男性与女性的脂肪比确定的双能X线吸收仪。结果：三分位组间体重、体重指数、体脂百分比无显著性差异。与男性与女性脂肪比的较低三分位数（三分位数1，1.67 [1.24]）相比，男性与女性脂肪比的2个较高三分位数（平均值[SD]，三分位数2，2.73 [1.41];三分位数3，2.89 [1.28]）的HOMA-IR值显著增加（P <0.001）。HOMA-IR值与男性/女性脂肪比例显著相关（r = 0.35; P <0.01）。结论：肥胖儿童和青少年的男性脂肪分布与胰岛素抵抗增加有关。基于双能x射线吸收测量的男性与女性脂肪比率是一种有用且简单的技术，可用于评估与胰岛素抵抗风险增加相关的体脂分布。
Background: Upper body fat distribution is associated with the early development of insulin resistance in obese children and adolescents.Objective: To determine if an android to gynoid fat ratio is associated with the severity of insulin resistance in obese children and adolescents, whereas peripheral subcutaneous fat may have a protective effect against insulin resistance.Setting: The pediatric department of University Hospital, Clermont-Ferrand, France.Design: A retrospective analysis using data from medical consultations between January 2005 and January 2007.Participants: Data from 66 obese children and adolescents coming to the hospital for medical consultation were used in this study.Main Outcome Measures: Subjects were stratified into tertiles of android to gynoid fat ratio determined by dual-energy x-ray absorptiometry. Insulin resistance was assessed by the homeostasis model of insulin resistance (HOMA-IR) index.Results: There were no differences in weight, body mass index, and body fat percentage between tertiles. Values of HOMA-IR were significantly increased in the 2 higher tertiles (mean [SD], tertile 2, 2.73 [1.41]; tertile 3, 2.89 [1.28]) compared with the lower tertile (tertile 1, 1.67 [1.24]) of android to gynoid fat ratio (P < .001). The HOMA-IR value was significantly associated with android to gynoid fat ratio (r = 0.35; P < .01).Conclusions: Android fat distribution is associated with an increased insulin resistance in obese children and adolescents. An android to gynoid fat ratio based on dual-energy x-ray absorptiometry measurements is a useful and simple technique to assess distribution of body fat associated with an increased risk of insulin resistance.