Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout".
Comparative phenotypic resolution of spontaneous, D2-like and D1-like agonist-induced orofacial movement topographies in congenic mutants with dopamine D2 vs. D3 receptor "knockout".
复制标题
在多巴胺 D2 与 D3 受体“敲除”的同源突变体中，自发、D2 样和 D1 样激动剂诱导的口面部运动地形的比较表型解析。
DOI：
10.1002/syn.10284
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Waddington,JohnL
中科院分区：
文献类型：
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作者：
Tomiyama,Katsunori;McNamara,FergalN;Clifford,JeremiahJ;Kinsella,Anthony;Drago,John;Fuchs,Sara;Grandy,DavidK;Low,MalcolmJ;Rubinstein,Marcelo;Tighe,Orna;Croke,DavidT;Koshikawa,Noriaki;Waddington,JohnL
使用一种新的系统，在具有同源D2 vs的突变小鼠中评估了D2样多巴胺受体在口面运动的不同地形中的作用。D3受体基因敲除后，与D1 A突变体的结果进行比较。在自发条件下，D2突变体证明增加垂直下颌运动和不变的水平下颌运动，减少舌头突出和门牙喋喋不休;在D3突变体，只有门牙喋喋不休减少。鉴于先前的证据表明，D1 A突变体显示水平而非垂直下颌运动减少，这表明在复合下颌运动的调节中明显的对立D1样：D2样相互作用实际上可能反映了D2受体抑制垂直下颌运动和D1 A受体促进水平下颌运动的独立作用。D2样激动剂RU 24213对水平下颌运动的抑制作用大于垂直下颌运动的抑制作用，在D2或D3突变体中均未发生显著改变。D1样激动剂A 68930和SK&F 83959诱导垂直下颌运动，舌头突出和门牙震颤;在D2突变体中，A 68930诱导舌头突出减少。D2受体发挥地形特异性调节口面运动的方式不同，从他们的D1 A对应，而D3受体发挥这种运动只有轻微的调节。Synapse 51：71-81，2004.© 2003 Wiley利斯公司
Using a novel system, the role of D2‐like dopamine receptors in distinct topographies of orofacial movement was assessed in mutant mice with congenic D2vs. D3receptor knockout, and compared with findings in D1Amutants. Under spontaneous conditions, D2mutants evidenced increased vertical jaw movements and unaltered horizontal jaw movements, with reductions in tongue protrusions and incisor chattering; in D3mutants, only incisor chattering was reduced. Given previous evidence that D1Amutants show reduced horizontal but not vertical jaw movements, this indicates that apparent oppositional D1‐like:D2‐like interactions in the regulation of composited jaw movements may in fact reflect the independent actions of D2receptors to inhibit vertical jaw movements and of D1Areceptors to facilitate horizontal jaw movements. Effects of the D2‐like agonist RU 24213 to exert greater reduction in horizontal than in vertical jaw movements were not altered prominently in either D2or D3mutants. The D1‐like agonists A 68930 and SK&F 83959 induced vertical jaw movements, tongue protrusions, and incisor chattering; induction of tongue protrusions by A 68930 was reduced in D2mutants. D2receptors exert topographically specific regulation of orofacial movements in a manner distinct from their D1Acounterparts, while D3receptors exert only minor regulation of such movements. Synapse 51:71–81, 2004. © 2003 Wiley‐Liss, Inc.