EXPERIMENTAL BLOCKAGE OF ENDOLYMPHATIC DUCT AND SAC AND ITS EFFECT ON INNER EAR OF GUINEA PIG - A STUDY ON ENDOLYMPHATIC HYDROPS
EXPERIMENTAL BLOCKAGE OF ENDOLYMPHATIC DUCT AND SAC AND ITS EFFECT ON INNER EAR OF GUINEA PIG - A STUDY ON ENDOLYMPHATIC HYDROPS
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DOI：
10.1177/000348946707600311
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发表时间：
1967-01-01
影响因子：
1.4
通讯作者：
KIMURA, RS
中科院分区：
文献类型：
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作者：
KIMURA, RS
在手术闭塞内淋巴管和囊的所有61只豚鼠中，术后14个月观察到内淋巴积水;所有对照组保持正常。对另外27只豚鼠进行了其他实验，包括电烙术、在鳃盖边缘切开并打开囊、切开导管、将异物和组织块插入囊内，结果导致5例耳蜗积水。本研究中的证据支持该部位的阻塞是产生积液的原因。Reissner膜扩张和组织病理学变化持续缓慢数月。Corti器、血管纹和螺旋神经节的改变常见于顶转处。细胞萎缩和实验性水肿的病因可能的解释进行了讨论。电子显微镜检查结果从类似的水肿情况下，提出了特别强调的病理变化的感觉细胞和Reissner的膜。
In all 61 guinea pigs in which the endolymphatic duct and sac were obliterated surgically, endolymphatic hydrops was observed up to 14 months postoperatively; all controls remained normal. Additional experiments, involving electrocautery, incision and opening of the sac at the operculum rim, splitting open of the duct, insertion of foreign substances and tissue masses into the sac were performed on 27 other guinea pigs and resulted in 5 instances of cochlear hydrops. Evidence in the present study favors blockage of this site as a cause for the production of hydrops. Distention of Reissner''s membrane and histopathological change continues slowly for many months. Changes in the organ of Corti, stria vascularis and spiral ganglia are often seen at the apical turns. Possible explanations for cellular atrophy and etiology of experimental hydrops are discussed. Electron microscopic findings from similar hydrops cases are presented with particular emphasis on the pathological alteration of the sensory cell and Reissner''s membrane.