Adipocyte dedifferentiation in health and diseases.
Adipocyte dedifferentiation in health and diseases.
复制标题
健康与疾病中的脂肪细胞去分化。
DOI：
10.1042/cs20190128
复制
发表时间：
2019-10
期刊：
影响因子：
6
通讯作者：
Tongxing Song;S. Kuang
中科院分区：
文献类型：
--
作者：
Tongxing Song;S. Kuang
Adipose tissues collectively as an endocrine organ and energy storage are crucial for systemic metabolic homeostasis. The major cell type in the adipose tissue, the adipocytes or fat cells, are remarkably plastic and can increase or decrease their size and number to adapt to changes in systemic or local metabolism. Changes in adipocyte size occur through hypertrophy or atrophy, and changes in cell numbers mainly involve de novo generation of new cells or death of existing cells. Recently, dedifferentiation, whereby a mature adipocyte is reverted to an undifferentiated progenitor-like status, has been reported as a mechanism underlying adipocyte plasticity. Dedifferentiation of mature adipocytes has been observed under both physiological and pathological conditions. This review covers several aspects of adipocyte dedifferentiation, its relevance to adipose tissue function, molecular pathways that drive dedifferentiation, and the potential of therapeutic targeting adipocyte dedifferentiation in human health and metabolic diseases.
