Inhibition of bacterial growth, enterotoxin production, and spore outgrowth in strains of Bacillus cereus by bacteriocin AS-48
Inhibition of bacterial growth, enterotoxin production, and spore outgrowth in strains of Bacillus cereus by bacteriocin AS-48
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DOI：
10.1128/aem.68.3.1473-1477.2002
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发表时间：
2002-03-01
影响因子：
4.4
通讯作者：
Valdivia, E
中科院分区：
文献类型：
--
作者：
Abriouel, H;Maqueda, M;Valdivia, E
细菌素AS-48在较宽的pH范围内对蜡样芽孢杆菌的嗜温和嗜冷菌株具有较高的杀菌活性。AS-48对肠毒素产生菌LWL 1的抑制作用可被亚硝酸钠、乳酸钠和氯化钠增强。后者还增强AS-48对菌株CECT 131的活性。在7.5 μ g/ml的细菌素浓度下，菌株LWL 1的细菌生长和肠毒素产生被完全抑制。在亚抑制细菌素浓度下，肠毒素的产生明显减少，孢子形成延迟。完整的孢子对AS-48具有抗性，但在萌发过程中对AS-48逐渐敏感。
Bacteriocin AS-48 showed high bactericidal activity for mesophilic and psychrotrophic strains of Bacillus cereus over a broad pH range. AS-48 inhibition of the enterotoxin-producing strain LWL1 was enhanced by sodium nitrite, sodium lactate, and sodium chloride. The latter also enhanced AS-48 activity against strain CECT 131. Bacterial growth and enterotoxin production by strain LWL1 were completely inhibited at bacteriocin concentrations of 7.5 mug/ml. At subinhibitory bacteriocin concentrations, enterotoxin production decreased markedly and sporulation was delayed. Intact spores were resistant to AS-48 but became gradually sensitive to AS-48 during the course of germination.