THE INSULIN SECRETORY GRANULE
THE INSULIN SECRETORY GRANULE
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DOI：
10.1007/bf00265542
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发表时间：
1989-05-01
期刊：
影响因子：
8.2
通讯作者：
HUTTON, JC
中科院分区：
文献类型：
--
作者：
HUTTON, JC
胰腺B细胞的胰岛素分泌颗粒是一个复杂的细胞内细胞器，由多种具有不同催化活性和信使功能的蛋白质组成。随着B细胞肿瘤模型的出现以及免疫学和分子克隆技术的应用，近年来在阐明这些颗粒蛋白的结构和功能方面取得了很大的进展。这里选择了一些例子进行回顾。特别强调完全不同的颗粒蛋白质的活动是如何相互依赖的，以及这如何有助于细胞器的生物功能的协调和整合。
The insulin secretory granule of the pancreatic B cell is a complex intracellular organelle comprised of a many proteins with different catalytic activities and messenger functions. With the advent of tumour models of the B cells and the application of immunological and molecular cloning techniques considerable progress has been made in recent years towards the elucidation of the structure and function of these granule proteins. A number of examples are selected here for review. Particular emphasis given to how the activities of quite different granule proteins are interdependent and how this contributes to the co-ordination and integration of the organelle's biological functions.