Early life high-fat diet exposure evokes normal weight obesity
Early life high-fat diet exposure evokes normal weight obesity
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DOI：
10.1186/s12986-020-00464-w
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发表时间：
2020-06-24
影响因子：
4.5
通讯作者：
Shimomura, Kenju
中科院分区：
文献类型：
--
作者：
Maejima, Yuko;Yokota, Shoko;Shimomura, Kenju
肥胖正在成为最严重的全球健康问题之一。然而，发展正常体重肥胖症的风险正在受到关注，因为这些个体也发展全身性炎症和代谢失调，其中个体尽管身体质量指数正常，但体脂肪百分比高。在这项研究中，幼年（3周龄）和成年（8周龄）大鼠喂食高脂饮食（HFD）9周，并将其与正常饮食（NCD）喂养的大鼠进行比较。与年龄匹配的NCD组相比，HFD喂养的成年组显示能量摄入、体重（BW）、总脂肪、内脏脂肪和皮下脂肪增加。此外，成人HFD组的肌肉质量占BW的百分比显着低于NCD组。当HFD喂养开始从幼年期，有几乎没有差异的能量摄入和BW之间的HFD和NCD组。然而，青少年HFD组的总脂肪、内脏脂肪和皮下脂肪比年龄匹配的NCD组增加了1.7倍。与NCD组相比，青少年HFD组的肌肉质量占体重的百分比显著降低。此外，仅在幼年HFD组中观察到血浆胰岛素水平升高和胰岛素敏感性降低，而在成年HFD组中未观察到。这些结果表明，生长期饲喂高脂膳食可诱导胰岛素抵抗和正常体重肥胖。在这里，我们展示了一种生成正常体重肥胖模型的方法，以及当儿童暴露于高脂肪膳食时，对发展正常体重肥胖发出警报。
Obesity is becoming one of the most severe global health problems. However, risk of developing normal weight obesity, where an individual has a high percentage of body fat despite a normal body mass index, is gaining attention since such individuals also develop systemic inflammation and metabolic dysregulation. In this study, juvenile (3-week-old) and adult (8-week-old) rats were fed a high fat diet (HFD) for 9 weeks and compared them with normal chow diet (NCD) fed rats. The HFD fed adult group showed increase in energy intake, body weight (BW), total fat, visceral fat and subcutaneous fat compared with an age-matched NCD group. In addition, the percentage of muscle mass to BW in the adult HFD group was significantly lower compared with the NCD group. When HFD feeding was started from the juvenile stage, there were almost no differences in energy intake and BW between the HFD and NCD groups. However, the juvenile HFD group showed a 1.7-fold increase in total fat, visceral fat and subcutaneous fat compared with their age-matched NCD group. The percentage of muscle mass to BW was significantly lower in the juvenile HFD group compared with the NCD group. In addition, increased plasma insulin levels and decreased insulin sensitivity was observed only in juvenile HFD group, but not in adult HFD group. These results suggest that HFD feeding in growth period induces insulin resistance and normal weight obesity. Here we show a method for generating a normal weight obesity model, as well as raising the alarm for developing normal weight obesity when children are exposed to high-fat meals.