Aquaculture as yet another environmental gateway to the development and globalisation of antimicrobial resistance
Aquaculture as yet another environmental gateway to the development and globalisation of antimicrobial resistance
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DOI：
10.1016/s1473-3099(16)00100-6
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发表时间：
2016-07-01
影响因子：
56.3
通讯作者：
Dolz, Humberto J.
中科院分区：
文献类型：
--
作者：
Cabello, Felipe C.;Godfrey, Henry P.;Dolz, Humberto J.
Aquarium每年使用数百吨抗菌剂来预防和治疗细菌感染。这些抗菌剂进入水环境选择耐药细菌和耐药基因，并刺激细菌突变，重组和水平基因转移。水生和人类病原体耐药基因的潜在桥接导致新的抗微生物剂耐药细菌的出现以及它们及其抗微生物剂耐药基因向动物和人类群体的全球传播。防止水产养殖中抗生素过度使用的努力必须包括对所有利益相关者进行关于其对鱼类、人类和水生生态系统健康的有害影响的教育（同一健康的概念），并鼓励采取环境友好的疾病预防措施，包括疫苗、益生菌和噬菌体。采取这些措施是通过开发新的治疗剂来应对抗菌素耐药性的努力的重要补充，如果要在人类和兽医学中日益严重的抗菌素耐药性问题上取得进展的话。
Aquaculture uses hundreds of tonnes of antimicrobials annually to prevent and treat bacterial infection. The passage of these antimicrobials into the aquatic environment selects for resistant bacteria and resistance genes and stimulates bacterial mutation, recombination, and horizontal gene transfer. The potential bridging of aquatic and human pathogen resistomes leads to emergence of new antimicrobial-resistant bacteria and global dissemination of them and their antimicrobial resistance genes into animal and human populations. Efforts to prevent antimicrobial overuse in aquaculture must include education of all stakeholders about its detrimental effects on the health of fish, human beings, and the aquatic ecosystem (the notion of One Health), and encouragement of environmentally friendly measures of disease prevention, including vaccines, probiotics, and bacteriophages. Adoption of these measures is a crucial supplement to efforts dealing with antimicrobial resistance by developing new therapeutic agents, if headway is to be made against the increasing problem of antimicrobial resistance in human and veterinary medicine.