Cholinergic augmentation of lymphocyte-mediated cytotoxicity. A study of the cholinergic receptor of cytotoxic T lymphocytes.
Cholinergic augmentation of lymphocyte-mediated cytotoxicity. A study of the cholinergic receptor of cytotoxic T lymphocytes.
复制标题
胆碱能增强淋巴细胞介导的细胞毒性。
DOI：
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发表时间：
1974
影响因子：
11.1
通讯作者：
J. Merrill
中科院分区：
文献类型：
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作者：
T. Strom;A. Sytkowski;C. Carpenter;J. Merrill
胆碱能激动剂以前已被证明能增强致敏淋巴细胞损伤携带致敏性等位基因的细胞的能力。攻击淋巴细胞群体的胆碱能受体已经通过体外系统的药理学操作进行了研究，该系统定量了致敏攻击细胞介导的靶细胞损伤。数据显示，毒蕈碱配体在改变细胞毒性方面比烟碱剂更有效几个数量级。
Cholinergic agonists have previously been shown to augment the ability of sensitized lymphocytes to injure cells bearing the sensitizing alleantigens. The cholinergic receptor of the attacking lymphocyte population has been studied with pharmacological manipulation of an in vitro system that quantitates the injury mediated by sensitized attacking cells upon target cells. The data reveal that muscarinic ligands are several orders of magnitude more potent than nicotinic agents in altering cytotoxicity.