Immune Characteristics of IgA Nephropathy With Minimal Change Disease.
Immune Characteristics of IgA Nephropathy With Minimal Change Disease.
复制标题
IgA 肾病微小病变的免疫特征。
DOI：
10.3389/fphar.2021.793511
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发表时间：
2021
影响因子：
5.6
通讯作者：
Lv J
中科院分区：
文献类型：
--
作者：
Li H;Lu W;Li H;Liu X;Zhang X;Xie L;Lan P;Yu X;Dai Y;Xie X;Lv J
Background: IgA nephropathy (IgAN) has a high degree of heterogeneity in clinical and pathological features. Among all subsets of IgAN, the pathogenesis of IgAN with minimal change disease (MCD-IgAN) remained controversial. Methods: We analyzed the clinical and pathological characteristics of MCD-IgAN patients in a retrospective cohort. Patients diagnosed with IgAN, excluding MCD-IgAN, were randomly selected as controls. Levels of plasma galactose-deficient IgA1 (GdIgA1), IgG autoantibodies against GdIgA1, GdIgA1 deposition in the glomerulus, and inflammatory reactivity of circulating poly-IgA1 complexes to cultured mesangial cells were evaluated. Results: Patients with MCD-IgAN had significantly higher levels of proteinuria and estimated glomerular filtration rate (eGFR), lower levels of albumin and urine blood cells, and milder histological lesions by a light microscope compared to IgAN patients, which bears a resemblance to MCD. Lower levels of GdIgA1 (3.41 ± 1.68 vs. 4.92 ± 2.30 μg/ml, p = 0.009) and IgG antiglycan autoantibodies (23.25 ± 22.59 vs. 76.58 ± 71.22 IU/ml, p < 0.001) were found in MCD-IgAN patients than those in IgAN controls. Meanwhile, weaker fluorescence intensities of both IgA and GdIgA1 were observed in the glomerulus of MCD-IgAN patients compared to those in IgAN patients. Furthermore, poly-IgA1 complexes from MCD-IgAN patients induced weaker inflammatory effects on cultured mesangial cells than those from IgAN patients in vitro. Conclusion: The results demonstrated that MCD-IgAN cases represent a dual glomerulopathy, namely, mild IgAN with superimposed MCD, which furthermore provides substantial evidence for the corticosteroids therapy in MCD-IgAN patients as the guidelines recommended.
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影响因子：
4.5
作者：
Kim, Sun Moon;Moon, Kyung Chul;Oh, Kook-Hwan;Joo, Kwon Wook;Kim, Yon Su;Ahn, Curie;Han, Jin Suk;Kim, Suhnggwon
通讯作者：
Kim, Suhnggwon
影响因子：
6.1
作者：
Wang, Jinquan;Juan, Chenxia;Liu, Zhihong
通讯作者：
Liu, Zhihong
影响因子：
3.9
作者：
Cho, Won-Hee;Park, Seon-Hwa;Lee, Sang-Ho
通讯作者：
Lee, Sang-Ho
DOI：
10.2215/cjn.08600718
发表时间：
2019-03-07
影响因子：
9.8
作者：
Thompson, Aliza;Carroll, Kevin;Nachman, Patrick H.
通讯作者：
Nachman, Patrick H.
影响因子：
3.4
作者：
Li, Xiao-Wei;Liang, Shao-Shan;Liu, Zhi-Hong
通讯作者：
Liu, Zhi-Hong