Internal Lewis Acid Assisted Benzoic Acid Catalysis
Internal Lewis Acid Assisted Benzoic Acid Catalysis
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DOI：
10.1055/s-0031-1291048
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发表时间：
2012-07-01
影响因子：
2.6
通讯作者：
Mattson, Anita E.
中科院分区：
文献类型：
--
作者：
Auvil, Tyler J.;Mattson, Anita E.
介绍了内刘易斯酸辅助的苯甲酸衍生物作为新型低分子量单氢键给体催化剂用于硝基烯烃的活化。所选的2-硼基苯甲酸衍生物在吲哚与硝基烯烃的加成反应中得到了较好的产物收率。对照实验表明，内部刘易斯酸配位和羧酸官能度对这些催化剂的最佳性能是至关重要的。
Internal Lewis acid assisted benzoic acid derivatives are introduced as new low-molecular-weight single-hydrogen-bond donor catalysts for the activation of nitroalkenes. Selected 2-borylbenzoic acid derivatives gave good yields of products in the addition of indoles to nitroalkenes. Control experiments suggest that both the internal Lewis acid coordination and the carboxylic acid functionalities are critical to the optimal performance of these catalysts.