Long-term endoscopic remission in Crohn's disease after allogeneic hematopoietic stem cell transplantation for diffuse large B cell lymphoma: case report and literature review
Long-term endoscopic remission in Crohn's disease after allogeneic hematopoietic stem cell transplantation for diffuse large B cell lymphoma: case report and literature review
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异基因造血干细胞移植治疗弥漫性大B细胞淋巴瘤克罗恩病的长期内镜缓解：病例报告及文献复习
DOI：
10.1007/s12328-021-01389-4
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Masamune A.
中科院分区：
文献类型：
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作者：
Inomata Y;Kuroha M;Handa T;Shimoyama Y;Moroi R;Shiga H;Kakuta Y;Ichikawa S;Fukuhara N;Sato Y;Takahashi T;Masamune A.
一名31岁男性克罗恩病患者在接受英夫利西单抗治疗6年后出现鼻咽弥漫性大B细胞淋巴瘤。停用英夫利西单抗，并在利妥昔单抗、环磷酰胺、多柔比星、长春新碱和泼尼松化疗后达到完全缓解。然而，该患者随后出现严重症状性克罗恩病复发。开始阿达木单抗治疗，患者达到缓解。然而，3个月后，他遭受了淋巴瘤复发。停用阿达木单抗，患者接受进一步化疗（利妥昔单抗、依托泊苷、顺铂、甲泼尼龙和大剂量阿糖胞苷），并接受异基因造血干细胞移植。手术后，克罗恩病和淋巴瘤已保持完全缓解5年。关于异基因造血干细胞移植后克罗恩病缓解的报道有限。因此，我们提出这一病例报告和审查现有的文献异基因干细胞移植治疗克罗恩病。
A 31-year-old man with Crohn’s disease in remission after 6-year treatment with infliximab developed nasopharyngeal diffuse large B cell lymphoma. Infliximab was discontinued, and complete remission was achieved following chemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone. However, the patient subsequently experienced severely symptomatic Crohn’s disease relapse. Therapy with adalimumab was initiated, and the patient attained remission. However, after 3 months, he suffered a recurrence of the lymphoma. Adalimumab was discontinued, and the patient received further chemotherapy (with rituximab, etoposide, cisplatin, methylprednisolone, and high-dose cytarabine) treatment and underwent allogeneic hematopoietic stem cell transplantation. Following the procedure, Crohn’s disease and lymphoma have remained in complete remission for 5 years. There are limited reports on Crohn’s disease remission after allogeneic hematopoietic stem cell transplantation. Therefore, we present this case report and a review of the existing literature on allogeneic stem cell transplantation for Crohn’s disease.