Verification of myocardial contrast two-dimensional echocardiographic assessment of perfusion defects in ischemic myocardium.
Verification of myocardial contrast two-dimensional echocardiographic assessment of perfusion defects in ischemic myocardium.
复制标题
心肌造影二维超声心动图评估缺血心肌灌注缺陷的验证。
DOI：
10.1016/s0735-1097(84)80427-1
复制
发表时间：
1984
影响因子：
24
通讯作者：
Corday,E
中科院分区：
文献类型：
--
作者：
Sakamaki,T;Tei,C;Meerbaum,S;Shimoura,K;Kondo,S;Fishbein,MC;Y-Rit,J;Shah,PM;Corday,E
在21只闭胸犬上应用心肌声学造影二维超声心动图评价其对急性缺血心肌灌注不足程度的显示能力。在左前降支冠状动脉闭塞后，将搅拌的生理盐水-Renografin超声心动图造影剂注射到左主干冠状动脉中，并在左心室短轴横截面上勾画出表征灌注缺损的造影剂无回声区的大小。在13只犬中，在冠状动脉闭塞45分钟后和处死前注射单星蓝染料，以在等效切片中提供灌注不足区的解剖学描绘。通过对比二维超声心动图评估的灌注缺陷与单星蓝染料描绘的灌注缺陷相关性良好（r = 0.91）。在阻塞5小时时，还在另外8只狗中进行了对比超声心动图研究，之后用氯化三苯基四氮唑测量梗死面积。对比超声心动图轮廓的灌注不足相关，但略有高估坏死的程度（r = 0.88）。它的结论是，对比二维超声心动图可以检测和概述灌注不足的“危险区”在急性冠状动脉闭塞，并可能也允许评估心肌梗死的程度。
Myocardial contrast two-dimensional echocardiography was used in 21 closed chest dogs to assess its ability to delineate the extent of underperfused acutely ischemic myocardium. An agitated saline-Renografin echocardiographic contrast agent was injected into the left main coronary artery after left anterior descending coronary artery occlusion, and the size of the contrast echo-free area characterizing the perfusion defect was outlined in short-axis cross sections of the left ventricle. In 13 dogs, monastral blue dye was injected after 45 minutes of coronary artery occlusion and before sacrifice to provide anatomic delineation of underperfused zones in equivalent sections. Perfusion defects assessed by contrast two-dimensional echocardiography correlated well with those delineated by monastral blue dye (r = 0.91). Contrast echocardiographic study was also performed in eight other dogs at 5 hours of occlusion, after which infarct size was measured with triphenyl-tetrazolium-chloride. Contrast echocardiographic outline of the perfusion deficiency correlated but slightly overestimated the extent of necrosis (r = 0.88).It is concluded that contrast two-dimensional echocardiography can detect and outline the underperfused “risk area” during acute coronary artery occlusion, and may also permit assessment of the extent of myocardial infarction.