Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis in Pancreatic Cancer: A Prospective Pilot Study of Safety Using 10 mL versus 20 mL Alcohol.
Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis in Pancreatic Cancer: A Prospective Pilot Study of Safety Using 10 mL versus 20 mL Alcohol.
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DOI：
10.1155/2013/327036
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Dewitt J
中科院分区：
文献类型：
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作者：
Leblanc JK;Rawl S;Juan M;Johnson C;Kroenke K;McHenry L;Sherman S;McGreevy K;Al-Haddad M;Dewitt J
背景EUS-CPN中使用的酒精剂量没有标准化。目的是比较胰腺癌相关疼痛患者在EUS-CPN期间使用20 mL酒精与10 mL酒精的安全性。方法.选择20例患者在EUS-CPN期间接受10 mL或20 mL酒精。在基线、24小时和每周进行随访。在基线、第2周、第4周和此后每4周一次评估健康相关生活质量（HRQoL），直至疼痛恢复。结果两组均无严重并发症。在6例（30%）受试者中观察到轻微自限性不良反应，包括1例（5%）头晕、2例（10%）一过性腹泻和3例一过性恶心和呕吐。两组的疼痛缓解相似：10 mL组为80%，20 mL组为100%（P = 0.21）。10 mL和20 mL组的平均（± SD）疼痛缓解持续时间分别为7.9 ± 10.8周和8.4 ± 9.2周。每组中30%的患者疼痛完全缓解。结论.使用20 mL酒精的EUS-CPN是安全的。两组的临床结局相似。需要进一步调查以证实这些发现。
Background. The dose of alcohol used in EUS-CPN is not standardized. The objective was to compare the safety of 20 mL alcohol versus 10 mL alcohol during EUS-CPN for patients with pancreatic cancer-related pain. Methods. 20 patients were selected to receive 10 mL or 20 mL of alcohol during EUS-CPN. Followup was done at baseline, 24 hours, and weekly. Health-related quality of life (HRQoL) was assessed at baseline, week 2, week 4, and every 4 weeks thereafter until pain returned. Results. There were no major complications in both groups. Minor self-limited adverse effects were seen in 6 (30%) subjects and included lightheadedness in 1 (5%), transient diarrhea in 2 (10%), and transient nausea and vomiting in 3. Pain relief was similar in both groups: 80% in the 10 mL group and 100% in the 20 mL group (P = 0.21). The mean (± SD) duration of pain relief in the 10 mL and 20 mL groups was 7.9 ± 10.8 and 8.4 ± 9.2 weeks, respectively. 30% of patients in each group had complete pain relief. Conclusions. EUS-CPN using 20 mL of alcohol is safe. Similar clinical outcomes were seen in both groups. Further investigations to confirm these findings are warranted.