Stem/progenitor cells in pituitary organ homeostasis and tumourigenesis.
Stem/progenitor cells in pituitary organ homeostasis and tumourigenesis.
复制标题
DOI：
10.1530/joe-17-0258
复制
发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Martinez-Barbera JP
中科院分区：
文献类型：
--
作者：
Haston S;Manshaei S;Martinez-Barbera JP
在过去的十年中，已经提供了垂体干细胞存在的证据，使用的方法包括体外克隆形成试验，流式细胞仪侧群分析，免疫组化分析和遗传方法的组合。这些细胞已被证明能够自我更新，并进行多能分化，产生垂体前叶的所有激素谱系。此外，有证据表明它们有助于器官再生和对不断变化的生理需求的塑料反应。最近，干细胞样细胞已从垂体肿瘤中分离出来，提出了细胞学层次存在的可能性，与癌症干细胞范例保持一致。在这篇手稿中，我们回顾了垂体干细胞存在的证据，它们在维持器官稳态和调节其分化中的作用。此外，我们还探讨了垂体瘤中干细胞的新概念及其在这些疾病中的潜在作用。
Evidence for the presence of pituitary gland stem cells has been provided over the last decade using a combination of approaches including in vitro clonogenicity assays, flow cytometric side population analysis, immunohistochemical analysis and genetic approaches. These cells have been demonstrated to be able to self-renew and undergo multipotent differentiation to give rise to all hormonal lineages of the anterior pituitary. Furthermore, evidence exists for their contribution to regeneration of the organ and plastic responses to changing physiological demand. Recently, stem-like cells have been isolated from pituitary neoplasms raising the possibility that a cytological hierarchy exists, in keeping with the cancer stem cell paradigm. In this manuscript, we review the evidence for the existence of pituitary stem cells, their role in maintaining organ homeostasis and the regulation of their differentiation. Furthermore, we explore the emerging concept of stem cells in pituitary tumours and their potential roles in these diseases.