Changes in body mass index for individuals with and without schizophrenia, 1987-1996
Changes in body mass index for individuals with and without schizophrenia, 1987-1996
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DOI：
10.1016/s0920-9964(01)00256-0
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发表时间：
2002-06-01
影响因子：
4.5
通讯作者：
Allison, DB
中科院分区：
文献类型：
--
作者：
Homel, P;Casey, D;Allison, DB
新型或非典型抗精神病药物的出现改善了许多个体的治疗和生活质量。然而，许多这些新药物的体重增加程度比传统抗精神病药物更大，而且具有临床意义。为了更好地理解这一问题，我们评估了美国成年人中具有全国代表性的样本中精神分裂症患者与非精神分裂症患者的体重指数（BMI; kg/m(2)）水平以及超重和肥胖的患病率，并评估了1987年至1996年这十年间这些比率是否有变化，这是新型/非典型药物使用增加的时期。结果显示，精神分裂症患者的平均BMI明显高于非精神分裂症患者。从1987年到1996年，非精神分裂症人群的身体质量指数在整体上以及按性别和年龄分层时都显示出稳定而显著的增长。相比之下，精神分裂症患者群体的时间趋势呈现出更为复杂的模式。具体来说，对于大多数人群来说，几乎没有证据表明随着时间的推移BMI会有一个总的趋势。然而，在1830岁的女性精神分裂症患者中，近年来BMI急剧增加，导致年轻精神分裂症女性的肥胖率比非精神分裂症女性高得多。这种体重、年龄和性别特定时间趋势背后的机制尚不清楚。(C) 2002 Elsevier Science B.V.版权所有
The advent of the novel or atypical antipsychotic drugs has improved the treatment and quality of life for many individuals. However, many of these newer agents confer a degree of weight gain that is both greater than conventional antipsychotics and of a clinically meaningful magnitude. To better place this issue into perspective, we evaluated body mass index (BMI; kg/m(2)) levels and the prevalence of overweight and obesity among schizophrenic versus non-schizophrenic individuals among nationally representative samples of the US adult population and evaluated whether there were changes in these rates during the decade from 1987 to 1996, a period in which use of novel/atypical agents increased. Results showed that mean BMI for individuals with schizophrenia is significantly higher than individuals who are not schizophrenic. The non-schizophrenic population shows steady and significant gains in BMI from 1987 to 1996 both as a whole and when stratified by gender and age. In contrast, time trends among the population of schizophrenic individuals show a more complex pattern. Specifically, for most groups, there is little evidence of a general trend in BMI over time. However, among females with schizophrenia ages 1830, BMI has increased dramatically and significantly causing a much higher obesity rate among young women with schizophrenia in recent years relative to their non-schizophrenic counterparts. The mechanism that underlies this weight age and sex specific time trend is unclear. (C) 2002 Elsevier Science B.V. All rights reserved.