Sitagliptin and liraglutide reversed nigrostriatal degeneration of rodent brain in rotenone-induced Parkinson's disease
Sitagliptin and liraglutide reversed nigrostriatal degeneration of rodent brain in rotenone-induced Parkinson's disease
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DOI：
10.1007/s10787-017-0331-6
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发表时间：
2017-06-01
影响因子：
5.8
通讯作者：
El Sayed, Moushira I.
中科院分区：
文献类型：
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作者：
Badawi, Ghada A.;Abd El Fattah, Mai A.;El Sayed, Moushira I.
本研究调查了帕金森病（PD）鱼藤酮模型中促炎细胞因子和程序性黑质神经元死亡之间的可能关系。还研究了西格列汀和利拉鲁肽抑制炎症凋亡退行性过程的功效。通过十次皮下注射鱼藤酮（3 mg/kg/天，皮下注射）在雄性白化大鼠中诱导实验性 PD。在帕金森大鼠模型诱导后，所有治疗药物均给药16天。西格列汀和利拉鲁肽分别以三种不同的剂量水平（10-20-30mg/kg，口服）和（25-50-100μg/kg，皮下注射）给药。使用圆柱试验和僵直试验来检测每种药物的最佳剂量反应。西格列汀（30 mg/kg/天，口服）和利拉鲁肽（50 μg/kg，皮下注射）显示出统计学显着性（p
The present study investigated the possible relationship between pro-inflammatory cytokines and programmed nigral neuronal death in rotenone model of Parkinson's disease (PD). Sitagliptin and liraglutide efficacy to inhibit the inflammatory-apoptotic degenerative process were investigated, too. The experimental PD were induced in male albino rats by ten subcutaneously injections of rotenone (3 mg/kg/day, s.c). All treatment drugs were administered for 16 days after induction of Parkinson rat's model. Sitagliptin and liraglutide were administered in three different dose levels (10-20-30 mg/kg, p.o), (25-50-100 mu g/kg, s.c), respectively. Cylindrical and catalepsy tests were used to detect the optimum dose response of each drug. Sitagliptin (30 mg/kg/day, p.o) and liraglutide (50 mu g/kg, s.c.) showed statistically significant (p