A place for time: the spatiotemporal structure of neural dynamics during natural audition.
A place for time: the spatiotemporal structure of neural dynamics during natural audition.
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DOI：
10.1152/jn.00268.2013
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发表时间：
2013-11
影响因子：
2.5
通讯作者：
G. Stephens;C. Honey;U. Hasson
中科院分区：
文献类型：
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作者：
G. Stephens;C. Honey;U. Hasson
我们使用功能磁共振成像(FMRI)来分析神经对自然听觉刺激的反应。我们通过体素功率谱的形状来表征fMRI时间序列，发现神经动力学的时间尺度沿空间梯度变化，早期听觉皮质的动力学较快，而高阶脑区的动力学较慢。时间尺度梯度是通过在存在和不存在刺激的情况下对个体大脑的功率谱进行无监督的聚类来观察到的，并在听众之间共享的刺激锁定组件中得到增强。此外，本质上较快的动态发生在优先对瞬时刺激特征做出反应的区域，而内在较慢的动态发生在整合了较长时间尺度的刺激信息的区域。这些观察将内在神经动力学的时间尺度与信息处理的时间尺度联系起来，表明了跨大脑皮层的神经计算的时间组织原则。
We use functional magnetic resonance imaging (fMRI) to analyze neural responses to natural auditory stimuli. We characterize the fMRI time series through the shape of the voxel power spectrum and find that the timescales of neural dynamics vary along a spatial gradient, with faster dynamics in early auditory cortex and slower dynamics in higher order brain regions. The timescale gradient is observed through the unsupervised clustering of the power spectra of individual brains, both in the presence and absence of a stimulus, and is enhanced in the stimulus-locked component that is shared across listeners. Moreover, intrinsically faster dynamics occur in areas that respond preferentially to momentary stimulus features, while the intrinsically slower dynamics occur in areas that integrate stimulus information over longer timescales. These observations connect the timescales of intrinsic neural dynamics to the timescales of information processing, suggesting a temporal organizing principle for neural computation across the cerebral cortex.