Effects of somatostatin-14 and somatostatin-28 on bombesin-stimulated release of gastrin, insulin, and glucagon in the dog.
Effects of somatostatin-14 and somatostatin-28 on bombesin-stimulated release of gastrin, insulin, and glucagon in the dog.
复制标题
生长抑素 14 和生长抑素 28 对铃蟾肽刺激的狗体内胃泌素、胰岛素和胰高血糖素释放的影响。
作者：
N. Vaysse;L. Pradayrol;J. Chayvialle;F. Pignal;J. Estève;C. Susini;F. Descos;A. Ribet
生长抑素-14（S14）和生长抑素-28（S28）是一种新型的肠肽，其C-末端含有生长抑素十四肽，对蛙皮素刺激的胃泌素、胰岛素和胰高血糖素释放的影响进行了测试。在静脉输注蛙皮素时，胰高血糖素水平的增加是胃泌素的两倍，胰岛素的增加是胃泌素的8倍。生长抑素的血浆浓度没有改变。S14和S28抑制胃泌素、胰岛素和胰高血糖素的释放;胰岛素释放被最有效地抑制，胰高血糖素释放其次，胃泌素释放被最少地抑制。基于产生相等效应所需的外源剂量，S28在摩尔基础上比S14更有效，但基于产生相等效应所需的血浆浓度，S14和S28是等效的。
The effects of somatostatin-14 (S14) and somatostatin-28 (S28), a novel intestinal peptide containing somatostatin tetradecapeptide in its C-terminal position, on the bombesin-stimulated release of gastrin, insulin, and glucagon were tested. On iv infusion of bombesin, the increase in the level of glucagon was seen to be twice that of gastrin, and the insulin increase was 8 times that of gastrin. Plasma concentrations of somatostatin were not modified. S14 and S28 inhibited the release of gastrin, insulin, and glucagon; insulin release was inhibited most effectively, with glucagon release next, and gastrin release least inhibited. Based on the exogenous dose needed to produce equal effects, S28 was more potent than S14 on a molar basis, but based on the plasma concentrations needed to produce equal effects, S14 and S28 were equipotent.