Emerging tools to study enteric neuromuscular function.
Emerging tools to study enteric neuromuscular function.
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研究肠神经肌肉功能的新兴工具。
DOI：
10.1152/ajpgi.00049.2017
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Gulbransen,BrianD
中科院分区：
文献类型：
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作者：
Gulbransen,BrianD
研究肠神经肌肉功能提出了在其他系统中没有遇到的特定挑战。肠道具有复杂的细胞组成，研究生理肠道功能期间多种多细胞相互作用的方法受到限制。然而，光学、遗传学和生物工程领域的新技术正在出现，极大地扩展了研究肠道综合功能的能力。在这篇简短的综述中，我讨论了几个领域，这些技术的应用可能有利于正在进行的努力，以了解肠道神经肌肉功能。我特别关注可用于研究特定蜂窝网络的技术以及将活动与功能联系起来的机制。
Investigating enteric neuromuscular function poses specific challenges that are not encountered in other systems. The gut has a complex cellular composition, and methods to study diverse multicellular interactions during physiological gut functions have been limited. However, new technologies are emerging in optics, genetics, and bioengineering that greatly expand the capabilities to study integrative functions in the gut. In this mini-review, I discuss several areas where the application of these technologies could benefit ongoing efforts to understand enteric neuromuscular function. I specifically focus on technologies that can be applied to study specific cellular networks and the mechanisms that link activity to function.