A Finite Element Model to Investigate the Stability of Osteochondral Grafts Within a Human Tibiofemoral Joint
A Finite Element Model to Investigate the Stability of Osteochondral Grafts Within a Human Tibiofemoral Joint
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DOI：
10.1007/s10439-024-03464-6
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发表时间：
2024-03-06
影响因子：
3.8
通讯作者：
Wilcox，Ruth K.
中科院分区：
文献类型：
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作者：
Day，Gavin A.;Jones，Alison C.;Wilcox，Ruth K.
骨软骨移植在治疗关节软骨缺损方面表现出积极的效果，通过用一层由骨和软骨组成的圆柱形移植物代替受损区域。然而，引起接枝沉降的因素尚不清楚。本研究的目的是建立胫骨股骨关节内骨软骨移植物的有限元模型，用于研究影响移植物稳定性的参数。尸体股骨被用来实验校准骨特性和移植物骨摩擦力，用于相应的基于图像的有限元模型，由微CT扫描数据生成。软骨缺损和骨软骨移植修复的效果是通过进一步的体外试验检测接触压力变化来测量的。本病例中，股骨髁出现6个缺损，随后采用自体骨软骨移植物或金属钉进行治疗。建立了基于图像的匹配有限元模型，并对接触块进行了比较。骨材料性能和移植物骨摩擦力从最初的测试中成功校准，结果一致性良好（CCC = 0.87）。胫骨-股骨关节实验提供了一系列病例，这些病例在所得的压力图中得到了准确的描述，并在有限元模型中得到了很好的体现。软骨缺损和修复质量的实验测量在FE模型压力图中有很好的一致性。模型置信度是通过广泛的验证和灵敏度测试建立的。研究发现，要准确地反映移植物的行为，需要标本特异性的性质。最终产生的模型适用于一系列参数测试，以研究直接接枝稳定性。
Osteochondral grafting has demonstrated positive outcomes for treating articular cartilage defects by replacing the damaged region with a cylindrical graft consisting of bone with a layer of cartilage. However, factors that cause graft subsidence are not well understood. The aim of this study was to develop finite element (FE) models of osteochondral grafts within a tibiofemoral joint, suitable for an investigation of parameters affecting graft stability. Cadaveric femurs were used to experimentally calibrate the bone properties and graft-bone frictional forces for use in corresponding image-based FE models, generated from µCT scan data. Effects of cartilage defects and osteochondral graft repair were measured by examining contact pressure changes using further in vitro tests. Here, six defects were created in the femoral condyles, which were subsequently treated with osteochondral autografts or metal pins. Matching image-based FE models were created, and the contact patches were compared. The bone material properties and graft-bone frictional forces were successfully calibrated from the initial tests with good resulting levels of agreement (CCC = 0.87). The tibiofemoral joint experiment provided a range of cases that were accurately described in the resultant pressure maps and were well represented in the FE models. Cartilage defects and repair quality were experimentally measurable with good agreement in the FE model pressure maps. Model confidence was built through extensive validation and sensitivity testing. It was found that specimen-specific properties were required to accurately represent graft behaviour. The final models produced are suitable for a range of parametric testing to investigate immediate graft stability.