Natural products against renin-angiotensin system for antifibrosis therapy
Natural products against renin-angiotensin system for antifibrosis therapy
复制标题
抗肾素-血管紧张素系统的天然产物用于抗纤维化治疗
DOI：
10.1016/j.ejmech.2019.06.091
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发表时间：
2019
影响因子：
6.7
通讯作者：
Zhao Ying-Yong
中科院分区：
文献类型：
--
作者：
Yang Tian;Chen Yuan-Yuan;Liu Jing-Ru;Zhao Hui;Vaziri Nosratola D.;Guo Yan;Zhao Ying-Yong
纤维化是许多慢性疾病的最终病理特征，但针对纤维化发病机制的干预措施很少。纤维化的常见细胞和分子机制的重点促进了有效的抗纤维化药物的发现。肾素-血管紧张素系统(RAS)在控制血压和体液平衡方面起着重要的生理作用。新出现的证据表明，RAS的激活一直存在于纤维化组织中。与此同时，随着RAS的更多成分的描述，其他POT潜在的治疗靶点也出现了，因此重新审视RAS在抗纤维化治疗中的贡献似乎是明智的。到目前为止，血管紧张素转换酶抑制剂(ACEI)和血管紧张素II 1型受体阻滞剂(ARB)是干预RAS的主要商用药物。然而，由于血管紧张素转换酶和醛固酮逃逸的发生，RAS抑制剂在长期应用中有很大的局限性。在过去的几十年里，天然产物作为潜在的RAS抑制剂，由于其高效和低副作用的风险而引起了越来越多的关注。在这篇综述中，我们回顾了RAS及其新成员对抗纤维化治疗的贡献。最后，我们总结和评价了天然产物，包括分离化合物、粗提物和传统中草药配方来调节RAS的使用。这些天然产物可以通过靶向不同的RAS成分来延缓组织纤维化，这为我们发现抗纤维化药物提供了新的治疗策略。
Fibrosis is a final pathological feature of many chronic diseases, but few interventions are available that specifically target the pathogenesis of fibrosis. The highlights of common cellular and molecular mechanisms of fibrosis facilitate the discovery of effective antifibrotic drugs. The renin-angiotensin system (RAS) plays a central physiological role in the control of blood pressure and fluid homeostasis. Emerging evidence has revealed that activation of RAS was consistently found in fibrotic tissue. At the same time, as more components of the RAS are described, other pot Potential therapeutic targets emerge, so it seems sensible to revisit the contribution of RAS in anti-fibrotic therapy. So far, angiotensin converting enzyme inhibitors (ACEI) and angiotensin II type 1 receptor blockers (ARB) are the main commercial available drugs for intervening RAS. However, RAS inhibitors had lots of limitations in long-term application owing to occurring AngII and aldosterone escape. Over the past decades, natural products have aroused growing attention as potential RAS inhibitors due to their high efficacy and low risk of side effects. In this review, we revisit the contribution of RAS and its new members to anti-fibrotic therapy. Ultimately, we summarize and evaluate the use of natural products including isolated compounds, crude extracts and traditional Chinese herbal formulas to regulate RAS. These natural products can retard tissue fibrosis by targeting different RAS components, which provide us new therapeutic strategies to discover anti-fibrotic drugs.