Simultaneous optimization of cryoprobe placement and thermal protocol for cryosurgery
Simultaneous optimization of cryoprobe placement and thermal protocol for cryosurgery
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DOI：
10.1088/0031-9155/46/7/305
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发表时间：
2001-07-01
影响因子：
3.5
通讯作者：
Muldrew, K
中科院分区：
文献类型：
--
作者：
Baissalov, R;Sandison, GA;Muldrew, K
我们证明，在一个冻融循环中，可以同时优化多个冷冻探头的放置位置及其热方案。采用了一种数值优化算法，并从算法收敛速度的角度考察了三种不同形式的目标函数。所选目标函数的最小值，温度-体积直方图和等温线分布。优化结果取决于变量的初始值。给出了目标函数的形式、优化目标和梯度计算采用的数学方法。与先前报道的适形冷冻治疗的半经验方法相比，提出的优化模型具有显著优势。例如能够处理无限数量的变量，并消除迭代之间用户输入的需要，从而减少（如果不能消除）冷冻手术治疗计划的主观性。
We demonstrate that it is possible to simultaneously optimize multiple cryoprobe placements and their thermal protocol for one freeze-thaw, cycle. A numerical optimization algorithm is used and three different forms of objective function are examined in terms of algorithm convergence rate. minimum value of the chosen objective function, temperature-volume histograms and isotherm distributions. The optimization results depend on the initial values of the variables. the form of the objective function, optimization goals and the mathematical method adopted for gradient calculation. The proposed optimization model offers significant advantages over the previously reported semi-empirical approach to conformal cryotherapy. such as the ability to handle an unlimited number of variables and eliminating the need for the user input between iterations, thereby reducing, if not removing the subjectivity of cryosurgery treatment planning.