Diffusion Tensor Imaging in Preclinical Huntington's Disease
Diffusion Tensor Imaging in Preclinical Huntington's Disease
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DOI：
10.1007/s11682-008-9051-2
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发表时间：
2009-03-01
影响因子：
3.2
通讯作者：
Paulsen, Jane S.
中科院分区：
文献类型：
--
作者：
Magnotta, Vincent A.;Kim, Jinsuh;Paulsen, Jane S.
扩散张量成像被用于研究脑白质的相关变化，这些变化可能与亨廷顿病的进展有关。对31例临床前基因突变携带者进行了弥散张量成像和脑解剖成像。受试者是具有已知的HD基因突变但没有表现出HD的运动诊断标准的个体。分数各向异性标量图显示壳核的五年诊断概率(基于基因重复长度和当前年龄)呈正相关，而外囊的则呈负相关。这项研究表明，扩散张量成像产生的标量图可能与HD疾病进展的最早阶段直接相关，甚至在给出诊断之前。因此，研究结果表明，在临床试验中，DTI测量可能有能力作为疾病进展的生物标记物。
Diffusion tensor imaging was used to study brain related changes in white matter that may be associated with Huntington's Disease progression. Thirty-one preclinical gene-mutation carriers were imaged cross-sectionally using diffusion tensor and anatomical brain imaging. Subjects were individuals who had a known gene mutation for HD but did not manifest motor diagnostic criteria for HD. Fractional anisotropy scalar maps showed a positive correlation with five year probability of diagnosis (based upon gene repeat length and current age) in the putamen and a negative correlation in the external capsule. This study shows that scalar maps generated from diffusion tensor imaging may be directly related to the earliest stages of disease progression within HD, even before a diagnosis is given. Findings suggest that DTI measures, therefore, may have the ability to act as a biomarker for disease progression in clinical trials of pre-manifest subjects.