Single-molecule insights into mRNA dynamics in neurons.
Single-molecule insights into mRNA dynamics in neurons.
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DOI：
10.1016/j.tcb.2015.05.005
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发表时间：
2015-08
影响因子：
19
通讯作者：
Park HY
中科院分区：
文献类型：
--
作者：
Buxbaum AR;Yoon YJ;Singer RH;Park HY
mRNA靶向神经元树突和轴突在细胞内信号传导、发育和突触可塑性中起着不可或缺的作用。神经元和脑组织中mRNA的单分子成像增强了对mRNA动力学的理解。在这里，我们讨论的mRNA调控方面所揭示的单分子检测，这导致定量分析mRNA的多样性，定位，运输和翻译。这些令人兴奋的新发现推动了我们对神经元中mRNA的生命以及其活性如何在单分子水平上受到调节的理解。
Targeting of mRNAs to neuronal dendrites and axons plays an integral role in intracellular signaling, development and synaptic plasticity. Single molecule imaging of mRNAs in neurons and brain tissue has led to enhanced understanding of mRNA dynamics. Here we discuss aspects of mRNA regulation as revealed by single molecule detection, which has led to quantitative analyses of mRNA diversity, localization, transport, and translation. These exciting new discoveries propel our understanding of the life of an mRNA in neurons and how its activity is regulated at the single molecule level.