A balanced translocation (17;22) and a pericentric inversion of chromosome 5. Repository identification No. GM3196.
A balanced translocation (17;22) and a pericentric inversion of chromosome 5. Repository identification No. GM3196.
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平衡易位 (17;22) 和 5 号染色体的中心倒位。保藏编号：GM3196。
DOI：
10.1159/000131498
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Coriell,LL
中科院分区：
文献类型：
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作者：
Testa,JR;Rowley,JD;Hawkins,C;Yu,RL;Aronson,MM;Mulivor,RA;Greene,AE;Coriell,LL
成纤维细胞培养建立于临床正常的31岁白人女性皮肤活检。该细胞系描述为44，xx, inv (5)(pter-+ pl3:: ql3-*-pl3:: ql3-* qter), t (17,22)（17qter->-17pl3:: 22qll-*-22qter; 22pter-> 22qll:: 17pl3->-17pter）。患者表现为习惯性流产，8年内有3次妊娠，均以自然流产告终，1次在4′/2月龄，2次在3月龄。她的核型，由G-， Q-和c -带测定，显示17号染色体和22号染色体之间的平衡易位加上5号染色体在所有细胞中的中心周围反转。父亲的母亲
This fibroblast culture was established from a skin biopsy of a clinically normal 31-year-old white female. This cell line is described as 46, XX, inv (5)(pter-+ pl3:: ql3-*-pl3:: ql3-* qter), t (17; 22)(17qter->-17pl3:: 22qll-*-22qter; 22pter-> 22q ll:: 17pl3->-17pter). The patient presented with habitual abortion, having had three pregnancies in eight years, all terminating in spontaneous abortion, one at 4'/2 months, the other two at 3 months. Her karyotype, determined by G-, Q-, and C-banding, showed a balanced translocation between chromosome 17 and 22 plus a pericentric inversion of chromo some 5 in all cells. The mother of the pa-