Transient increase in renal epidermal growth factor content after unilateral nephrectomy in the mouse.
Transient increase in renal epidermal growth factor content after unilateral nephrectomy in the mouse.
复制标题
小鼠单侧肾切除术后肾表皮生长因子含量短暂增加。
DOI：
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Y. Saito
中科院分区：
文献类型：
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作者：
S. Kanda;P. K. Saha;K. Nomata;M. Taide;N. Nishimura;T. Igawa;J. Yamada;H. Kanetake;Y. Saito
建立了一种灵敏的小鼠肾脏表皮生长因子的酶联免疫吸附测定方法，用于单肾切除后残留肾脏中表皮生长因子的测定。5周龄雄性小鼠单肾切除前肾组织表皮生长因子含量为355+/-97 ng/g湿组织，术后第1天增加2.1倍，以后逐渐下降。在15周龄的成年雄性小鼠中，单肾切除后第一天肾脏表皮生长因子的含量增加了1.7倍。免疫组织化学分析显示，单肾切除后第1天，远端肾小管上皮细胞表达表皮生长因子，染色强度增强。在肾脏代偿性生长过程中，血浆和颌下腺中的表皮生长因子含量没有明显变化。我们的数据表明，单肾切除后肾脏表皮生长因子含量的增加是由于肾脏本身表皮生长因子的产生增加。讨论了这一现象的意义。
A sensitive enzyme-linked immunosorbent assay for mouse epidermal growth factor was established for measurement of the content of epidermal growth factor in the remaining kidney after uninephrectomy. In 5-week-old male mice, the renal epidermal growth factor content before uninephrectomy was 355 +/- 97 ng/g wet tissue with a 2.1-fold increase on the first day after uninephrectomy, whereafter it gradually decreased. In 15-week-old mature male mice, the renal epidermal growth factor content increased 1.7-fold on the first day after uninephrectomy. Immunohistochemical analysis showed that epidermal growth factor was present in the distal tubular cells and that the staining intensity was increased on the first day after uninephrectomy. During the course of compensatory renal growth, no significant alteration of epidermal growth factor content was observed in plasma or in the submaxillary gland. Our data suggest that the increase in renal epidermal growth factor content after uninephrectomy is due to an increased production of epidermal growth factor in the kidney itself. The significance of this phenomenon is discussed.
DOI：
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发表时间：
1981
期刊：
Investigative urology
影响因子：
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作者：
Kanetake,H;Yamamoto,N
通讯作者：
Yamamoto,N
影响因子：
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作者：
NORMAN, J;BADIEDEZFOOLY, B;FINE, LG
通讯作者：
FINE, LG
慢性肾功能衰竭成人的血清生长调节素水平：测量酸色谱尿毒症血清中胰岛素样生长因子 I (IGF-I) 和 IGF-II 的重要性。
DOI：
10.1210/jcem-63-5-1186
发表时间：
1986
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
Powell,DR;Rosenfeld,RG;Baker,BK;Liu,F;Hintz,RL
通讯作者：
Hintz,RL