Influence of hyperbaric oxygen therapy on peri-implant bone healing in rats with alloxan-induced diabetes
Influence of hyperbaric oxygen therapy on peri-implant bone healing in rats with alloxan-induced diabetes
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DOI：
10.1111/j.1600-051x.2012.01922.x
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发表时间：
2012-09-01
影响因子：
6.7
通讯作者：
Cury, Patricia Ramos
中科院分区：
文献类型：
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作者：
Dutra Oliveira, Peterson Antonio;Soares Dutra Oliveira, Alcione Maria;Cury, Patricia Ramos
目的 研究高压氧治疗 (HBOT) 对四氧嘧啶诱导的 1 型糖尿病大鼠种植体周围骨愈合的影响。材料与方法 48只雄性大鼠随机分为6组：（1）未接受HBOT的健康大鼠（HR）； (2) 种植体安装前接受过 10 次 HBOT 的 HR； (3)种植体安装后接受10次HBOT的HR； (4)未进行HBOT的诱导糖尿病(DR)大鼠； (5) 种植体安装前接受过 10 次 HBOT 治疗的 DR； (6) 种植体安装后接受 10 次 HBOT 的 DR。将螺丝形钛植入物插入股骨中。植入后28天处死动物。评估种植体螺纹内骨与种植体接触 (BIC) 的百分比。结果 与 HR (69.07 +/- 09.01) 相比，DR (35.35 +/- 18.04) 的 BIC 较低 (p = 0.001)。然而，对于 HBOT，无论是植入之前还是植入之后，DR 中的 BIC 都会增加。植入前 HBOT 为 p = 0.03；植入后 HBOT 为 p = 0.08。这种增加逆转了糖尿病的负面影响；因此，HBOT 时 DR 和 HR 之间的差异不显着 (p = 0.21)。结论 HBOT，无论是植入前还是植入后，均可将 DR 中的 BIC 提高至 HR 水平
Aim The influence of hyperbaric oxygen therapy (HBOT) on peri-implant bone healing in rats with alloxan-induced type-1 diabetes was studied. Materials and methods Forty-eight male rats were randomly divided into six groups: (1) healthy rats (HR) that received no HBOT; (2) HR that underwent 10 sessions of HBOT before implant installation; (3) HR that underwent 10 sessions of HBOT after implant installation; (4) rats with induced diabetes (DR) without HBOT; (5) DR that underwent 10 sessions of HBOT before implant installation; (6) DR that underwent 10 sessions of HBOT after implant installation. A screw-shaped titanium implant was inserted into the femur. The animals were killed 28 days after implantation. The percentage of bone-to-implant contact (BIC) within the implant threads was evaluated. Results Lower BIC was observed in DR (35.35 +/- 18.04) compared with the HR (69.07 +/- 09.01) (p = 0.001). However, with HBOT, either before or after implantation, BIC was increased in DR. HBOT before implantation was p = 0.03; HBOT after implantation was p = 0.08. This increase reversed the negative effect of diabetes; therefore, the differences between DR and HR were not significant with HBOT (p = 0.21). Conclusion HBOT, either before or after implantation, increased the BIC in DR to the level of HR