Polymeric albumin in the urine of patients with nephrotic syndrome.
Polymeric albumin in the urine of patients with nephrotic syndrome.
复制标题
肾病综合征患者尿液中的聚合白蛋白。
作者：
W. Boesken;F. Schindera;M. Billingham;J. Hardwicke;R. White;A. Williams
在部分肾病综合征患者的尿液中检测到二聚体和聚合物白蛋白。大部分以S-S键合的二聚体和聚合物形式存在；然而，可以证明与免疫球蛋白和α(1)抗胰酶的共聚物。提示白蛋白通过肾小球膜后发生聚合。白蛋白二聚体主要与患者的微小病变和早期膜性肾小球病变有关，这些患者总体上对治疗反应良好。
Dimer and polymer albumin was detected in the urine of a proportion of pantients with a nephrotic syndrome. Most of it was present as S-S bonded dimer and polymer; co-polymers, however, with IgG and alpha (1) anti-trypsin could be demonstrated. It is suggested that albumin polymerizes after it has passed the glomerular membrane. Albumin dimer was associated mainly with minimal change disease and early membranous glomerulopathy in patients, who in general responded well to therapy.