Comorbidity of fibromyalgia and psychiatric disorders
Comorbidity of fibromyalgia and psychiatric disorders
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DOI：
10.4088/jcp.v67n0807
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发表时间：
2006-08-01
影响因子：
5.3
通讯作者：
Hess, Evelyn V.
中科院分区：
文献类型：
--
作者：
Arnold, Lesley M.;Hudson, James I.;Hess, Evelyn V.
目的：为了评估纤维肌痛与精神疾病的共同发生在参与者的纤维肌痛family study.Method：患者（先证者）与纤维肌痛，控制先证者与类风湿性关节炎，和一级亲属的两组完成了结构化的临床访谈和招标点检查。共现比值比（OR）计算（患有纤维肌痛的个体终生共患DSM-IV疾病的几率除以不患有纤维肌痛的个体终生共患疾病的几率，根据年龄和性别进行调整）;观察结果根据先证者的纤维肌痛状态通过选择的逆概率进行加权;标准误差根据家庭内观察结果的相关性进行调整。研究时间为1999年9月至2002年4月。结果：我们评估了78名纤维肌痛先证者及其146名亲属，以及40名类风湿关节炎先证者及其72名亲属。在有纤维肌痛的个体与无纤维肌痛的个体中，特定疾病的共现OR如下：双相情感障碍：153（95%CI = 26 - 902，p
Objective: To assess the co-occurrence of fibromyalgia with psychiatric disorders in participants of a fibromyalgia family study.Method: Patients (probands) with fibromyalgia, control probands with rheumatoid arthritis, and first-degree relatives of both groups completed a structured clinical interview and tender point examination. The co-occurrence odds ratio (OR) (the odds of a lifetime comorbid DSM-IV disorder in an individual with fibromyalgia divided by the odds of a lifetime comorbid disorder in an individual without fibromyalgia, adjusted for age and sex) was calculated; observations were weighted by the inverse probability of selection, based on the fibromyalgia status of the proband; and standard errors were adjusted for the correlation of observations within families. The study was conducted from September 1999 to April 2002.Results: We evaluated 78 fibromyalgia probands and 146 of their relatives, and 40 rheumatoid arthritis probands and 72 of their relatives: Among the relatives of both proband groups, we identified 30 cases of fibromyalgia, bringing the total number of individuals with fibromyalgia to 108, compared with 228 without fibromyalgia. The co-occurrence ORs for specific disorders in individuals with versus those without fibromyalgia were as follows: bipolar disorder: 153 (95% CI= 26 to 902, p