Dragonfly-shaped near-infrared AIEgen with optimal fluorescence brightness for precise image-guided cancer surgery
Dragonfly-shaped near-infrared AIEgen with optimal fluorescence brightness for precise image-guided cancer surgery
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蜻蜓形近红外 AIEgen 具有最佳荧光亮度，适用于精确图像引导癌症手术
DOI：
10.1016/j.biomaterials.2020.120036
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发表时间：
2020-07-01
期刊：
影响因子：
14
通讯作者：
Tang, Ben Zhong
中科院分区：
文献类型：
--
作者：
Qi, Ji;Duan, Xingchen;Tang, Ben Zhong
同时具有高吸收系数和光致发光量子产率（PLQY）的有机近红外（NIR）发光体在生物医学成像中非常理想，但很少报道，因为这两个方面通常是矛盾的。共轭平面结构的分子在聚集态有很强的吸收，但发射严重猝灭，而扭曲非平面结构的分子则表现出相反的现象。在此，我们报道了一种蜻蜓形状的近红外聚集诱导发射发光体（AlEgen），其具有高吸收系数（6.24 x 104 M-1 cm（-1））和上级的PLQY（51.2%），用于精确的图像引导癌症手术。合成了一种具有共轭结构和振动取代基的化合物，良好的共轭结构使其具有强吸收，分子振动提供了AIE信号。此外，非荧光过程被显着抑制，尽一切努力提高荧光。高亮度和稳定的AIE纳米颗粒保证了有效的体外细胞成像和体内肿瘤成像。此外，荧光成像引导的癌症手术有助于精确描绘微小的肿瘤结节，显著改善癌症手术结果。这项工作将激发更多的见解，为生物医学应用的高亮度有机近红外发射器的发展。
Organic near-infrared (NIR) emitters with simultaneously high absorption coefficient and photoluminescence quantum yield (PLQY) are highly desirable for biomedical imaging yet seldom reported because these two aspects are usually contradictory. The conjugated planar structures exhibit strong absorption but the emission is seriously quenched in aggregate state, whereas the twisted unplanar molecules display opposite phenomena. Herein, we report a kind of dragonfly-shaped NIR aggregation-induced emission luminogen (AlEgen) with both high absorption coefficient (6.24 x 104 M-1 cm(-1)) and superior PLQY (51.2%) for precise image-guided cancer surgery. The compound possessing a conjugated structure with vibrational substitutes has been synthesized, in which the good conjugation enables strong absorption, and the molecular vibration affords AIE signature. Moreover, the nonfluorescent processes are significantly suppressed, making every effort to boost fluorescence. The highly bright and stable AIE nanoparticles warrant efficient in vitro cellular imaging and in vivo tumor imaging. Moreover, the fluorescence imaging-guided cancer surgery helps to precisely delineate tiny tumor nodules, significantly improving the cancer surgery outcome. This work will inspire more insights into the development of organic NIR emitters with high brightness for biomedical applications.