Bone marrow origin of Ia-positive cells in the medulla rat thymus.
Bone marrow origin of Ia-positive cells in the medulla rat thymus.
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DOI：
10.1084/jem.153.6.1666
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发表时间：
1981-06-01
期刊：
影响因子：
--
通讯作者：
Mayrhofer G
中科院分区：
文献类型：
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作者：
Barclay AN;Mayrhofer G
用F1杂种的骨髓对受照射的大鼠进行重建。通过免疫过氧化物酶技术在低温恒温器切片上检测到供体骨髓来源的Ia抗原，并且在重建2周后主要在大鼠胸腺髓质中发现。这些携带Ia的细胞在重建后的数量随时间增加，但皮质上皮细胞上的Ia仍然是宿主来源的。讨论了骨髓来源细胞的性质及其对主要组织相容性复合体限制的影响。
Irradiated rats were reconstituted with bone marrow from F1 hybrids. Ia antigen of donor-bone marrow origin was detected by an immunoperoxidase technique on cryostat sections and found predominantly in the medulla of rat thymus 2 wk after reconstitution. These Ia-bearing cells increased in number with time after reconstitution, but the Ia on the cortical epithelial cells remained of host origin. The nature of the bone marrow-derived cells and their implication for major histocompatibility complex restriction are discussed.