THE T-CELL RECEPTOR
THE T-CELL RECEPTOR
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DOI：
10.1126/science.3317824
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发表时间：
1987-11-20
期刊：
影响因子：
56.9
通讯作者：
KAPPLER, J
中科院分区：
文献类型：
--
作者：
MARRACK, P;KAPPLER, J
T细胞受体蛋白和基因的一级结构已被充分理解。免疫学家现在正试图了解这些有趣分子的特性。有证据表明，T细胞αβ受体识别与主要组织相容性复合体（MHC）基因的细胞表面产物之一结合的抗原衍生肽的复合物。αβ受体和MHC蛋白可能共同进化，彼此具有一定的亲和力。在胸腺中的T细胞发育期间，携带自身反应性受体的细胞通过耐受机制被删除，并且如果细胞在成为成熟的T细胞后携带能够识别抗原和自身MHC的受体，则优先允许细胞成熟。对这些现象的一些解释已经得到了检验，但还没有令人满意的理论来解释它们。
The primary structure of T cell receptor proteins and genes is well understood. Immunologists are now trying to understand the properties of these interesting molecules. Evidence suggests that T cell αβ receptors recognize a complex of an antigen-derived peptide bound to one of the cell-surface products of the major histocompatibility complex (MHC) genes. It is likely that αβ receptors and MHC proteins have coevolved to have some affinity for each other. During T cell development in the thymus, cells bearing self-reactive receptors are deleted by the mechanisms of tolerance, and cells are preferentially allowed to mature if they bear receptors that will be able to recognize antigen plus self-MHC after they have become full-fledged T cells. Some explanations for these phenomena have been tested, but no satisfactory theory can yet be proposed to account for them.