A continuous-flow resonator-type microwave reactor for high-efficiency organic synthesis and Claisen rearrangement as a model reaction
A continuous-flow resonator-type microwave reactor for high-efficiency organic synthesis and Claisen rearrangement as a model reaction
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用于高效有机合成和克莱森重排模型反应的连续流谐振器型微波反应器
DOI：
10.1007/s41981-018-0021-6
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发表时间：
2018
影响因子：
2.7
通讯作者：
Okamoto Tadashi
中科院分区：
文献类型：
--
作者：
Koyama Emiko;Ito Noriko;Sugiyama Jun-ichi;Barham Joshua P.;Norikane Yasuo;Azumi Reiko;Ohneda Noriyuki;Ohno Yoshinobu;Yoshimura Takeo;Odajima Hiromichi;Okamoto Tadashi
我们研制了一种具有多种操作方法的连续流合成单模微波反应器。该装置测量谐振频率并相应地调节振荡频率以保持腔内最大电场强度。它既可以使用恒定的辐照功率，也可以使用改变电功率（E-GRA）和改变流量（Fl-GRA）的新程序，以便快速筛选各种反应条件。作为模型反应，在该装置上快速优化了烯丙基1-萘醚1的Claisen重排反应，以高达91%的产率和高达20 g/h的产率获得了所需的产物2-烯丙基萘-1-醇2。
We have developed a single-mode microwave reactor for continuous-flow synthesis with various methods of operation. This device measures the resonant frequency and modulates the oscillation frequency accordingly to maintain the maximum electric field intensity in the cavity. It can be operated either using constant applied irradiation power or using new programs which change the electric power (E-GRA) and change the flow rate (Fl-GRA), in order to rapidly screen various reaction conditions. As a model reaction, the Claisen rearrangement reaction of allyl 1-naphthyl ether 1 was rapidly optimized in this device, affording the desired product 2-allylnapthalen-1-ol 2 in high (91%) yield and up to 20 g/h productivity.