LYSERGIC-ACID DIETHYLAMIDE - EFFECT ON HISTONE ACETYLATION IN RABBIT BRAIN
LYSERGIC-ACID DIETHYLAMIDE - EFFECT ON HISTONE ACETYLATION IN RABBIT BRAIN
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DOI：
10.1126/science.1215990
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发表时间：
1975-01-01
期刊：
影响因子：
56.9
通讯作者：
LIEW, CC
中科院分区：
文献类型：
--
作者：
BROWN, IR;LIEW, CC
麦角酸二乙酰胺以每公斤体重10和100微克的剂量静脉内给药后30分钟，可增加兔大脑半球和中脑中组蛋白的乙酰化。通过聚丙烯酰胺凝胶电泳分离后，获得了单个组蛋白条带乙酰化刺激的证据。
Lysergic acid diethylamide increased acetylation of histones in rabbit cerebral hemispheres and midbrain 30 minutes after intravenous administration of the drug at doses of 10 and 100 micrograms per kilogram of body weight. Evidence for the stimulation of acetylation in individual histone bands was obtained after separation by electrophoresis on polyacrylamide gels.