β-endorphin: Effects on respiratory regulation
β-endorphin: Effects on respiratory regulation
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β-内啡肽：对呼吸调节的影响
DOI：
10.1016/0024-3205(78)90505-2
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发表时间：
1978
期刊：
影响因子：
6.1
通讯作者：
E. Friedman
中科院分区：
文献类型：
--
作者：
I. R. Moss;E. Friedman
在浅麻醉犬脑室内注射14.5nmol人β-内啡肽可引起明显的呼吸抑制，表现为对二氧化碳重复呼吸的呼吸机能和气道闭塞压反应减弱。这些反应可通过静脉注射纳洛酮暂时逆转，并在第二次注射β-内啡肽后减弱。本研究结果提示内源性阿片肽可能在呼吸调节中发挥生理学作用。
Intracisternal injection of 14.5 nmoles of human β-endorphin in lightly anesthetized dogs resulted in marked respiratory depression, manifested by diminished responses of ventilation and airway occlusion pressure to carbon dioxide rebreathing. These responses were temporarily reversed by intravenous injection of naloxone and attenuated following a second β-endorphin injection. Results in this study suggest a possible physiological role for endogenous opioid peptides in the regulation of respiration.